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Ketofol 1:3 ratio
Ketofol is a fixed-ratio combination of ketamine and propofol that produces rapid sedation and anesthesia through dual action on NMDA receptors and GABA-A receptors.
Ketofol is a fixed-ratio combination of ketamine and propofol that produces rapid sedation and anesthesia through dual action on NMDA receptors and GABA-A receptors. Used for Induction and maintenance of general anesthesia, Sedation in intensive care settings.
At a glance
| Generic name | Ketofol 1:3 ratio |
|---|---|
| Sponsor | Kasr El Aini Hospital |
| Drug class | Anesthetic combination |
| Target | NMDA receptor (ketamine); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ketamine acts as an NMDA receptor antagonist providing dissociative anesthesia and analgesia, while propofol is a GABA-A receptor agonist that enhances inhibitory neurotransmission. The 1:3 ratio combines ketamine's analgesic and dissociative properties with propofol's rapid onset and smooth sedation profile, potentially reducing the adverse effects of each agent when used alone.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care settings
Common side effects
- Hypotension
- Respiratory depression
- Emergence reactions (dissociation)
- Injection site pain
- Apnea
Key clinical trials
- Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECT (PHASE4)
- Oropharyngeoesophageal Topical Anesthesia Versus Propofol - Ketamine Sedation for Upper Gastrointestinal Endoscopy (NA)
- Ketamin Plus Propofol for Anesthesia Induction (PHASE4)
- Ketofol Versus Propofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients. (NA)
- Two Ratios of Propofol-ketamine Admixture for Rapid-sequence Induction Anesthesia for Emergency Laparotomy (PHASE4)
- The Effect of Anesthesia Management on Optic Nerve Sheath Diameter in the Ercp Procedures (NA)
- Neuroprotection During Open Heart Surgery (PHASE3)
- Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketofol 1:3 ratio CI brief — competitive landscape report
- Ketofol 1:3 ratio updates RSS · CI watch RSS
- Kasr El Aini Hospital portfolio CI