Who are Epithelium-Off Riboflavin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Epi-Off, Riboflavin/Dextran, Epithelium-On Riboflavin.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Epithelium-Off Riboflavin — Competitive Intelligence Brief

Epithelium-Off Riboflavin (Epithelium-Off Riboflavin) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Corneal cross-linking agent. Area: Ophthalmology.

phase 3 Corneal cross-linking agent Corneal collagen (indirect via riboflavin photosensitization) Ophthalmology Small molecule Live · refreshed every 30 min

Target snapshot

Epithelium-Off Riboflavin (Epithelium-Off Riboflavin) — Crowd Health Research, LTD. Epithelium-off riboflavin uses ultraviolet A light activation of riboflavin to create reactive oxygen species that cross-link corneal collagen, strengthening the cornea.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Epithelium-Off Riboflavin TARGET	Epithelium-Off Riboflavin	Crowd Health Research, LTD	phase 3	Corneal cross-linking agent	Corneal collagen (indirect via riboflavin photosensitization)
Epi-Off	Epi-Off	Icahn School of Medicine at Mount Sinai	phase 3	Corneal cross-linking agent	Corneal collagen (riboflavin-mediated photochemical cross-linking)
Riboflavin/Dextran	Riboflavin/Dextran	Cornea and Laser Eye Institute	phase 3	Corneal cross-linking agent	Corneal collagen (indirect via photochemical cross-linking)
Epithelium-On Riboflavin	Epithelium-On Riboflavin	Crowd Health Research, LTD	phase 3	Corneal cross-linking agent	Corneal collagen (photochemical cross-linking via riboflavin and UVA)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Corneal cross-linking agent class)

Crowd Health Research, LTD · 2 drugs in this class
Cornea and Laser Eye Institute · 1 drug in this class
Icahn School of Medicine at Mount Sinai · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Epithelium-Off Riboflavin — Competitive Intelligence Brief. https://druglandscape.com/ci/epithelium-off-riboflavin. Accessed 2026-05-16.

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