Who are Epipen's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Precedex, Flivas, Dapiprazole Hydrochloride, Hytrin, Sudafed PE, Levonordefrin.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

How do I get this as a recurring report?

Subscribe to /feed/ci/epinephrine.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-13 · How we verify

Epipen — Competitive Intelligence Brief

Epipen (epinephrine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: alpha-Adrenergic Agonist [EPC]. Area: Cardiovascular.

marketed alpha-Adrenergic Agonist [EPC] Alpha-1D adrenergic receptor Cardiovascular Live · refreshed every 30 min

Target snapshot

Epipen (epinephrine) — Pfizer Inc.. Epipen works by stimulating the alpha-1D adrenergic receptor to rapidly increase heart rate, blood pressure, and bronchodilation.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Epipen TARGET	epinephrine	Pfizer Inc.	marketed	alpha-Adrenergic Agonist [EPC]	Alpha-1D adrenergic receptor	1948-01-01
Precedex	dexmedetomidine	Bioxcel	marketed	Central alpha-2 Adrenergic Agonist	Alpha-1D adrenergic receptor	1999-01-01
Flivas	NAFTOPIDIL	Asahi Kasei	marketed	naftopidil	Alpha-1D adrenergic receptor	1999-01-01
Dapiprazole Hydrochloride	DAPIPRAZOLE	Fera Pharms	marketed	alpha-Adrenergic Blocker	Alpha-1D adrenergic receptor	1990-01-01
Hytrin	TERAZOSIN		marketed	alpha-Adrenergic Blocker	Alpha-1D adrenergic receptor	1987-01-01
Sudafed PE	phenylephrine	Generic (multiple manufacturers)	marketed	Alpha-1 adrenergic agonist (decongestant/vasopressor)	Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-1D adrenergic receptor	1976-01-01
Levonordefrin	corbadrine	Eastman Kodak	marketed	corbadrine	Alpha-1D adrenergic receptor, Adrenergic receptor alpha-2, Adrenergic receptor alpha-1	1960-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2026-12-12 — Epipen · 11590286 · Formulation · US
2027-02-27 — Epipen · 8206360 · Formulation · US
2028-03-12 — Epipen · 7947017 · Formulation · US
2028-11-25 — Epipen · 8231573 · Formulation · US
2029-04-10 — Epipen · 8226610 · Formulation · US
2029-11-02 — Epipen · 8021344 · Formulation · US
2035-03-13 — Epipen · 12280024 · Formulation · US
2035-03-13 — Epipen · 9295657 · Method of Use · US
2035-03-13 — Epipen · 10130592 · Formulation · US
2035-03-13 — Epipen · 9119876 · Formulation · US
2036-10-20 — Epipen · 11141540 · Formulation · US
2037-12-21 — Epipen · 10842938 · Formulation · US
2037-12-21 — Epipen · 11771830 · Formulation · US
2037-12-21 — Epipen · 10688244 · Formulation · US
2038-02-06 — Epipen · 10576156 · Formulation · US
2038-02-06 — Epipen · 11173209 · Method of Use · US
2039-02-06 — Epipen · 11918655 · Method of Use · US
2039-02-06 — Epipen · 12324838 · Formulation · US
2039-02-06 — Epipen · 10682414 · Method of Use · US
2039-02-06 — Epipen · 11191838 · Formulation · US
2039-02-06 — Epipen · 11717571 · Method of Use · US
2039-02-06 — Epipen · 11744895 · Method of Use · US
2039-03-21 — Epipen · 12133837 · Formulation · US
2039-03-21 — Epipen · 11207280 · Formulation · US
2039-03-21 — Epipen · 10653646 · Formulation · US
2039-03-21 — Epipen · 11083698 · Method of Use · US
2045-01-17 — Epipen · 12539283 · Formulation · US

Sponsor landscape (alpha-Adrenergic Agonist [EPC] class)

· 2 drugs in this class
Pfizer Inc. · 2 drugs in this class
Provepharm Sas · 1 drug in this class

Subscribe to ongoing alerts

Push every new event for this competitive set into your RSS reader, IFTTT/Zapier workflow, or email digest:

Cite this brief

Drug Landscape (2026). Epipen — Competitive Intelligence Brief. https://druglandscape.com/ci/epinephrine. Accessed 2026-05-13.

Build your own brief

Pick any drug + add comparators:

https://druglandscape.com/ci/{slug} — auto-detected competitors
https://druglandscape.com/ci/{slug}?vs=drug1,drug2,drug3 — explicit comparators
Brand names auto-resolve: /ci/keytruda → 301 → /ci/pembrolizumab