Last reviewed · How we verify
Levonordefrin (corbadrine)
At a glance
| Generic name | corbadrine |
|---|---|
| Sponsor | Eastman Kodak |
| Drug class | corbadrine |
| Target | Alpha-1D adrenergic receptor, Adrenergic receptor alpha-2, Adrenergic receptor alpha-1 |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
| First approval | 1960 |
Approved indications
Common side effects
- Dizziness
- Blurred vision
- Tremors
- Nervousness
- Drowsiness
- Sweating
- Edema
- Localized puffiness and swelling
- Cutaneous lesions
- Urticaria
Serious adverse events
- Convulsions
- Respiratory arrest
- Unconsciousness
- Cerebral hypoxia
- Seizure
- Cardiovascular catastrophe
- Anaphylactoid reactions
- Hypersensitivity reactions
Key clinical trials
- Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor (NA)
- Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock (NA)
- Assessment of Clinical & Radiographic Efficiency of Manual & Pediatric Rotary Systems in Primary Root Canal Preparation (NA)
- Insertion of Immediate Cortical Satellite Implants With Immediate Loading (NA)
- Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L in Children (PHASE3)
- Effect of Sodium Alendronate on the Final Implant Stability. (EARLY_PHASE1)
- Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial. (NA)
- Pain Assessment During Mandibular Nerve Block Injection With the Aid of Dental Vibe Tool in Pediatric Dental Patients (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Levonordefrin CI brief — competitive landscape report
- Levonordefrin updates RSS · CI watch RSS
- Eastman Kodak portfolio CI