Who are ELX/TEZ/IVA's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Ivacaftor/Ataluren, LUM/IVA, Ivacaftor+lumacaftor, Elexacaftor / Ivacaftor / Tezacaftor, Lumacaftor plus Ivacaftor, Placebo matched to VX-661/ ivacaftor.

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Last reviewed 2026-06-10 · How we verify

ELX/TEZ/IVA — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

ELX/TEZ/IVA (ELX/TEZ/IVA) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: CFTR modulator combination. Area: Respiratory / Genetic Disease.

phase 3 CFTR modulator combination CFTR (cystic fibrosis transmembrane conductance regulator) Respiratory / Genetic Disease Small molecule Live · refreshed every 30 min

Target snapshot

ELX/TEZ/IVA (ELX/TEZ/IVA) — Vertex Pharmaceuticals Incorporated. ELX/TEZ/IVA is a triple combination of CFTR modulators that work together to restore function of the cystic fibrosis transmembrane conductance regulator protein.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
ELX/TEZ/IVA TARGET	ELX/TEZ/IVA	Vertex Pharmaceuticals Incorporated	phase 3	CFTR modulator combination	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor/Ataluren	Ivacaftor/Ataluren	University of Alabama at Birmingham	marketed	CFTR modulator combination	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
LUM/IVA	LUM/IVA	Vertex Pharmaceuticals Incorporated	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor+lumacaftor	Ivacaftor+lumacaftor	Assistance Publique - Hôpitaux de Paris	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Elexacaftor / Ivacaftor / Tezacaftor	Elexacaftor / Ivacaftor / Tezacaftor	Nottingham University Hospitals NHS Trust	marketed	CFTR modulator combination (correctors + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Lumacaftor plus Ivacaftor	Lumacaftor plus Ivacaftor	Hannover Medical School	phase 3	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Placebo matched to VX-661/ ivacaftor	Placebo matched to VX-661/ ivacaftor	Vertex Pharmaceuticals Incorporated	phase 3	CFTR modulator combination (corrector + potentiator)	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (CFTR modulator combination class)

University of Alabama at Birmingham · 1 drug in this class
Vertex Pharmaceuticals Incorporated · 1 drug in this class

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Cite this brief

Drug Landscape (2026). ELX/TEZ/IVA — Competitive Intelligence Brief. https://druglandscape.com/ci/elx-tez-iva. Accessed 2026-06-10.

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