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Last reviewed 2026-06-10 · How we verify

Therapeutic opioid induced constipation — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Therapeutic opioid induced constipation (disease) competitive landscape: 5 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

5 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Therapeutic opioid induced constipation, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	First approval
Symproic	NALDEMEDINE	Bdsi	Opioid Antagonist	Mu-type opioid receptor	2017-01-01
Movantik	NALOXEGOL	Averitas	Opioid Antagonist	Mu-type opioid receptor	2014-01-01
Relistor	METHYLNALTREXONE	Salix Pharms	Opioid Antagonist	Mu-type opioid receptor	2008-01-01
Naltrexon	Naltrexon	Institute of Liver and Biliary Sciences, India		Neuronal acetylcholine receptor subunit alpha-7, Cytochrome P450 2D6, Delta-type opioid receptor
Movantik	Movantik	AstraZeneca		Mu-type opioid receptor

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

AstraZeneca · 1 drug in Therapeutic opioid induced constipation
Averitas · 1 drug in Therapeutic opioid induced constipation
Bdsi · 1 drug in Therapeutic opioid induced constipation
Institute of Liver and Biliary Sciences, India · 1 drug in Therapeutic opioid induced constipation
Salix Pharms · 1 drug in Therapeutic opioid induced constipation

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Cite this brief

Drug Landscape (2026). Therapeutic opioid induced constipation — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/therapeutic-opioid-induced-constipation. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing