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Last reviewed 2026-06-10 · How we verify

Sickling disorder due to hemoglobin S — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sickling disorder due to hemoglobin S (disease) competitive landscape: 4 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

4 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Sickling disorder due to hemoglobin S, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Target
Siklos	Siklos	Theravia	Carbonic anhydrase 2, Carbonic anhydrase 5A, mitochondrial, Carbonic anhydrase 9
Xromi	Xromi	Nova Laboratories Limited	Carbonic anhydrase 2, Carbonic anhydrase 5A, mitochondrial, Carbonic anhydrase 9
Hydroxycarbamide	Hydroxycarbamide	University of Birmingham	Carbonic anhydrase 2, Carbonic anhydrase 5A, mitochondrial, Carbonic anhydrase 9
Hydroxycarbamid	Hydroxycarbamid	Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts	Carbonic anhydrase 2, Carbonic anhydrase 5A, mitochondrial, Carbonic anhydrase 9

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts · 1 drug in Sickling disorder due to hemoglobin S
Nova Laboratories Limited · 1 drug in Sickling disorder due to hemoglobin S
Theravia · 1 drug in Sickling disorder due to hemoglobin S
University of Birmingham · 1 drug in Sickling disorder due to hemoglobin S

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Every new regulatory action, PDUFA date, or trial completion in Sickling disorder due to hemoglobin S:

Cite this brief

Drug Landscape (2026). Sickling disorder due to hemoglobin S — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/sickling-disorder-due-to-hemoglobin-s. Accessed 2026-06-10.

Sickling disorder due to hemoglobin S full disease profile — treatment pathway, diagnostics, guidelines
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing