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Last reviewed 2026-06-10 · How we verify

Moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to TNF blockers — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to TNF blockers (disease) competitive landscape: 1 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

1 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to TNF blockers, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	Line of therapy	First approval
Rinvoq	upadacitinib	AbbVie Inc.	JAK inhibitor	Janus kinase (JAK) enzymes, particularly JAK1 and JAK2

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

AbbVie Inc. · 1 drug in Moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to TNF blockers

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Every new regulatory action, PDUFA date, or trial completion in Moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to TNF blockers:

Cite this brief

Drug Landscape (2026). Moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to TNF blockers — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/moderately-to-severely-active-rheumatoid-arthritis-in-adults-with-inadequate-response-or-intolerance-to-tnf-blockers. Accessed 2026-06-10.

Moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to TNF blockers full disease profile — treatment pathway, diagnostics, guidelines
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing