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Last reviewed 2026-06-10 · How we verify

Moderate to Severe Ulcerative Colitis — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Moderate to Severe Ulcerative Colitis (disease) competitive landscape: 8 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

8 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Moderate to Severe Ulcerative Colitis, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	First approval
Etrasimod	etrasimod	Pfizer	Sphingosine 1-phosphate receptor modulator	Sphingosine 1-phosphate (S1P) receptors 1, 4, and 5	2023-01-01
tumor necrosis factor inhibitors (TNFi)	tumor-necrosis-factor-inhibitors-tnfi	Pfizer	biologic	tumor necrosis factor
TNF Inhibitor	tnf-inhibitor	Pfizer	Monoclonal Antibody	TNF-alpha
Chronic- PF-06480605 50 mg SC Q4W	chronic-pf-06480605-50-mg-sc-q4w	Pfizer	JAK inhibitor	JAK pathway
Velsipity	Etrasimod Arginine	Pfizer Inc.	Sphingosine 1-phosphate receptor modulator	Sphingosine 1-phosphate (S1P) receptors 1, 4, and 5
Induction- PF-06480605 150 mg SC Q4W	induction-pf-06480605-150-mg-sc-q4w	Pfizer	JAK inhibitor	JAK pathway
Chronic- PF-06480605 150 mg SC Q4W	chronic-pf-06480605-150-mg-sc-q4w	Pfizer	Janus kinase inhibitor	JAK1 and JAK2 enzymes
Induction- PF-06480605 450 mg SC Q4W	induction-pf-06480605-450-mg-sc-q4w	Pfizer	small molecule	IL-17 receptor

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

Pfizer · 7 drugs in Moderate to Severe Ulcerative Colitis
Pfizer Inc. · 1 drug in Moderate to Severe Ulcerative Colitis

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Cite this brief

Drug Landscape (2026). Moderate to Severe Ulcerative Colitis — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/moderate-to-severe-ulcerative-colitis. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing