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Last reviewed 2026-06-11 · How we verify

Malignant Melanoma with BRAF V600E Mutation — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Malignant Melanoma with BRAF V600E Mutation (disease) competitive landscape: 5 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

5 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Malignant Melanoma with BRAF V600E Mutation, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	First approval
Tafinlar	dabrafenib	Novartis	Kinase Inhibitor	Serine/threonine-protein kinase B-raf	2013-01-01
Mekinist	trametinib	Novartis	Kinase Inhibitor	Dual specificity mitogen-activated protein kinase kinase 2	2013-01-01
Tybost	COBICISTAT	Gilead Sciences	Cytochrome P450 3A Inhibitor [EPC]	Cytochrome P450 3A	2012-01-01
Zelboraf	vemurafenib	Hoffmann La Roche	Kinase Inhibitor [EPC]	Serine/threonine-protein kinase B-raf	2011-01-01
Zelboraf	Zelboraf	Hoffmann-La Roche		Aspartyl/asparaginyl beta-hydroxylase, Ferrochelatase, mitochondrial, Dual specificity mitogen-activated protein kinase kinase 5

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

Novartis · 2 drugs in Malignant Melanoma with BRAF V600E Mutation
Gilead Sciences · 1 drug in Malignant Melanoma with BRAF V600E Mutation
Hoffmann La Roche · 1 drug in Malignant Melanoma with BRAF V600E Mutation
Hoffmann-La Roche · 1 drug in Malignant Melanoma with BRAF V600E Mutation

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Every new regulatory action, PDUFA date, or trial completion in Malignant Melanoma with BRAF V600E Mutation:

Cite this brief

Drug Landscape (2026). Malignant Melanoma with BRAF V600E Mutation — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/malignant-melanoma-with-braf-v600e-mutation. Accessed 2026-06-11.

Malignant Melanoma with BRAF V600E Mutation full disease profile — treatment pathway, diagnostics, guidelines
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing