How many drugs treat Cluster headache syndrome?

Drug Landscape tracks 5 marketed treatments for Cluster headache syndrome (deduplicated by molecule). 0 Phase 3 candidates and 0 Phase 2 candidates are in the pipeline.

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Last reviewed 2026-06-10 · How we verify

Cluster headache syndrome — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cluster headache syndrome (disease) competitive landscape: 5 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

5 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Cluster headache syndrome, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	First approval
Imitrex	SUMATRIPTAN	GSK	Serotonin-1b and Serotonin-1d Receptor Agonist	5-hydroxytryptamine receptor 1D	1992-01-01
Norgesic	caffeine	Hikma	Central Nervous System Stimulant [EPC]	Adenosine receptor A2a	1948-01-01
Migranal	DIHYDROERGOTAMINE	Bausch Health	Ergotamine Derivative	D(3) dopamine receptor	1946-01-01
Ergot	Ergot	Samuel Lunenfeld Research Institute, Mount Sinai Hospital		5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6
phenobarbitone	phenobarbitone	Institute of Child Health		Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 1 group I member 3, GABA-A receptor alpha-1/beta-2/gamma-2

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

· 1 drug in Cluster headache syndrome
Bausch Health · 1 drug in Cluster headache syndrome
GSK · 1 drug in Cluster headache syndrome
Hikma · 1 drug in Cluster headache syndrome
Institute of Child Health · 1 drug in Cluster headache syndrome
Samuel Lunenfeld Research Institute, Mount Sinai Hospital · 1 drug in Cluster headache syndrome

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Every new regulatory action, PDUFA date, or trial completion in Cluster headache syndrome:

Cite this brief

Drug Landscape (2026). Cluster headache syndrome — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/cluster-headache-syndrome. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing