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Last reviewed 2026-06-10 · How we verify

Bipolar affective disorder, current episode manic — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Bipolar affective disorder, current episode manic (disease) competitive landscape: 10 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

10 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Bipolar affective disorder, current episode manic, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	First approval
Vraylar	CARIPRAZINE	AbbVie	Atypical Antipsychotic [EPC]	D(3) dopamine receptor	2015-01-01
Saphris	ASENAPINE	Hisamitsu	Atypical Antipsychotic [EPC]	5-hydroxytryptamine receptor 2C	2009-01-01
Abilify	aripiprazole	Generic (originally Otsuka/BMS)	Third-generation antipsychotic (D2 partial agonist)	5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6	2002-11-15
Geodon	ziprasidone	Pfizer Inc.	Atypical antipsychotic (second-generation)	Aspartate aminotransferase, cytoplasmic, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A	2001-02-05
Risperdal	risperidone	Johnson & Johnson (Janssen)	Atypical Antipsychotic [EPC]	5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6	1993-12-29
Lithium Citrate	LITHIUM CITRATE	Hikma	lithium	Glycogen synthase kinase-3	1980-01-01
Depakene	valproic acid	Generic (originally Abbott/AbbVie)	Anti-epileptic Agent [EPC]	Alcohol dehydrogenase [NADP(+)], Histone deacetylase 1, Histone deacetylase 2	1978-02-28
Lithobid	lithium carbonate	Generic (multiple manufacturers)	Mood stabilizer	Inositol-1(or 4)-monophosphatase 1, Glycogen synthase kinase-3	1970-04-06
Tegretol	carbamazepine	Novartis AG (originally Geigy)	Mood Stabilizer [EPC]	Frizzled-8, Nuclear receptor subfamily 1 group I member 2, Neuronal acetylcholine receptor; alpha2/beta4	1968-03-11
Thorazine	chlorpromazine	Generic (originally Rhône-Poulenc/Sanofi)	Typical antipsychotic (first-generation, phenothiazine)	Aldehyde oxidase, Sphingomyelin phosphodiesterase, 5-hydroxytryptamine receptor 1E	1954-03-26

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

· 1 drug in Bipolar affective disorder, current episode manic
AbbVie · 1 drug in Bipolar affective disorder, current episode manic
AstraZeneca · 1 drug in Bipolar affective disorder, current episode manic
Eli Lilly · 1 drug in Bipolar affective disorder, current episode manic
Enanta Pharmaceuticals, Inc · 1 drug in Bipolar affective disorder, current episode manic
Generic (multiple manufacturers) · 1 drug in Bipolar affective disorder, current episode manic
Generic (originally Abbott/AbbVie) · 1 drug in Bipolar affective disorder, current episode manic
Generic (originally Otsuka/BMS) · 1 drug in Bipolar affective disorder, current episode manic
Generic (originally Rhône-Poulenc/Sanofi) · 1 drug in Bipolar affective disorder, current episode manic
Hikma · 1 drug in Bipolar affective disorder, current episode manic
Hisamitsu · 1 drug in Bipolar affective disorder, current episode manic
Johnson & Johnson (Janssen) · 1 drug in Bipolar affective disorder, current episode manic

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Cite this brief

Drug Landscape (2026). Bipolar affective disorder, current episode manic — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/bipolar-affective-disorder-current-episode-manic. Accessed 2026-06-10.

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