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Last reviewed 2026-05-17 · How we verify

diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan (diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan) competitive landscape: 0 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Combination cold/cough/allergy remedy. Area: Respiratory/Cold and Cough.

marketed Combination cold/cough/allergy remedy H1 histamine receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); NMDA receptor and sigma-1 receptor (dextromethorphan) Respiratory/Cold and Cough Small molecule Live · refreshed every 30 min

Target snapshot

diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan (diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan) — Montefiore Medical Center. This combination product uses diphenhydramine as a sedating antihistamine, phenylephrine as a nasal decongestant, dextromethorphan as a cough suppressant, with cocoa as a flavoring agent, and includes a placebo control arm.

Comparator set

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan TARGET	diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan	Montefiore Medical Center	marketed	Combination cold/cough/allergy remedy	H1 histamine receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); NMDA receptor and sigma-1 receptor (dextromethorphan)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Combination cold/cough/allergy remedy class)

Montefiore Medical Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan — Competitive Intelligence Brief. https://druglandscape.com/ci/diphenhydramine-phenylephrine-cocoa-placebo-dextromethorphan. Accessed 2026-05-17.

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