Who are Dipeptidyl peptidase-4 inhibitors's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Metformin plus vildagliptin, sitagliptin and acarbose, Linagliptin / Metformin Oral Tablet, alogliptin + pioglitazone, Januvia (sitagliptin), Metformin and Saxagliptin.

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Last reviewed 2026-05-18 · How we verify

Dipeptidyl peptidase-4 inhibitors — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dipeptidyl peptidase-4 inhibitors (Dipeptidyl peptidase-4 inhibitors) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: DPP-4 inhibitor. Area: Diabetes.

phase 3 DPP-4 inhibitor Dipeptidyl peptidase-4 (DPP-4) Diabetes Small molecule Live · refreshed every 30 min

Target snapshot

Dipeptidyl peptidase-4 inhibitors (Dipeptidyl peptidase-4 inhibitors) — Ain Shams University. Dipeptidyl peptidase-4 inhibitors block the DPP-4 enzyme, which normally inactivates incretin hormones, thereby prolonging GLP-1 and GIP signaling to increase insulin secretion and lower blood glucose.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Dipeptidyl peptidase-4 inhibitors TARGET	Dipeptidyl peptidase-4 inhibitors	Ain Shams University	phase 3	DPP-4 inhibitor	Dipeptidyl peptidase-4 (DPP-4)
Metformin plus vildagliptin	Metformin plus vildagliptin	Sheba Medical Center	marketed	Biguanide + DPP-4 inhibitor combination	Metformin: mitochondrial glycerophosphate dehydrogenase; Vildagliptin: DPP-4 (dipeptidyl peptidase-4)
sitagliptin and acarbose	sitagliptin and acarbose	Nanjing First Hospital, Nanjing Medical University	marketed	DPP-4 inhibitor + alpha-glucosidase inhibitor combination	DPP-4 enzyme; alpha-glucosidase enzymes
Linagliptin / Metformin Oral Tablet	Linagliptin / Metformin Oral Tablet	Universidad de Guanajuato	marketed	DPP-4 inhibitor / Biguanide combination	DPP-4 (dipeptidyl peptidase-4) / AMPK pathway
alogliptin + pioglitazone	alogliptin + pioglitazone	Kun-Ho Yoon	marketed	DPP-4 inhibitor + thiazolidinedione	DPP-4 and PPAR-γ
Januvia (sitagliptin)	Januvia (sitagliptin)	Zealand University Hospital	marketed	DPP-4 inhibitor	DPP-4 (dipeptidyl peptidase-4)
Metformin and Saxagliptin	Metformin and Saxagliptin	ikfe-CRO GmbH	marketed	Biguanide + DPP-4 inhibitor combination	Metformin: mitochondrial glycerophosphate dehydrogenase; Saxagliptin: DPP-4 (dipeptidyl peptidase-4)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (DPP-4 inhibitor class)

Merck Sharp & Dohme LLC · 5 drugs in this class
Daewoong Pharmaceutical Co. LTD. · 4 drugs in this class
AstraZeneca · 4 drugs in this class
LG Life Sciences · 2 drugs in this class
Tanabe Pharma Corporation · 2 drugs in this class
Ain Shams University · 2 drugs in this class
Ono Pharmaceutical Co. Ltd · 2 drugs in this class
Cinnagen · 1 drug in this class
GRADE Study Group · 1 drug in this class
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Dipeptidyl peptidase-4 inhibitors — Competitive Intelligence Brief. https://druglandscape.com/ci/dipeptidyl-peptidase-4-inhibitors. Accessed 2026-05-18.

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