Depofoam bupivacaine — Competitive Intelligence Brief

Depofoam bupivacaine (Depofoam bupivacaine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic (liposomal formulation). Area: Anesthesia / Pain Management.

marketed Local anesthetic (liposomal formulation) Voltage-gated sodium channels Anesthesia / Pain Management Small molecule

Target snapshot

Depofoam bupivacaine (Depofoam bupivacaine) — The Cleveland Clinic. Depofoam bupivacaine is a liposomal formulation of the local anesthetic bupivacaine that provides prolonged anesthesia by slowly releasing bupivacaine from lipid vesicles.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Depofoam bupivacaine TARGET	Depofoam bupivacaine	The Cleveland Clinic	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
Lidocaine 5% patch	Lidocaine 5% patch	Beijing Tiantan Hospital	marketed	Local anesthetic	Voltage-gated sodium channels
Buffered Articaine Hydrochloride + Epinephrine	Buffered Articaine Hydrochloride + Epinephrine	Ohio State University	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Synera(TM)	Synera(TM)	IWK Health Centre	marketed	Topical local anesthetic	Voltage-gated sodium channels
Ropivacaine + Ketamine	Ropivacaine + Ketamine	Aga Khan University	marketed	Local anesthetic + NMDA receptor antagonist combination	Voltage-gated sodium channels (ropivacaine); NMDA receptor (ketamine)
lamotrigine (brand Lamictal)	lamotrigine (brand Lamictal)	University of Maryland, Baltimore	marketed	Anticonvulsant / Mood stabilizer	Voltage-gated sodium channels; glutamate release inhibition
Naropeine (Ropivacaine)	Naropeine (Ropivacaine)	Nantes University Hospital	marketed	Local anesthetic (amide)	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic (liposomal formulation) class)

1. Pacira Pharmaceuticals, Inc · 4 drugs in this class
2. Huazhong University of Science and Technology · 1 drug in this class
3. Maimonides Medical Center · 1 drug in this class
4. The Cleveland Clinic · 1 drug in this class
5. The Cooper Health System · 1 drug in this class
6. The University of Texas Health Science Center, Houston · 1 drug in this class
7. Tianjin Medical University General Hospital · 1 drug in this class
8. University of California, Davis · 1 drug in this class
9. Catherine Vandepitte, M.D. · 1 drug in this class
10. Wake Forest University Health Sciences · 1 drug in this class