Who are Comtess®'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Levodopa/carbidopa/entacapone, sinemet plus.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

How do I get this as a recurring report?

Subscribe to /feed/ci/comtess.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-13 · How we verify

Comtess® — Competitive Intelligence Brief

Comtess® (Comtess®) competitive landscape: 2 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: COMT inhibitor. Area: Neurology.

marketed COMT inhibitor Catechol-O-methyltransferase (COMT) Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Comtess® (Comtess®) — Orion Corporation, Orion Pharma. Comtess inhibits catechol-O-methyltransferase (COMT), an enzyme that breaks down levodopa, thereby prolonging levodopa's therapeutic effect in the brain.

Comparator set (2 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Comtess® TARGET	Comtess®	Orion Corporation, Orion Pharma	marketed	COMT inhibitor	Catechol-O-methyltransferase (COMT)
Levodopa/carbidopa/entacapone	Levodopa/carbidopa/entacapone	Novartis	marketed	Dopamine precursor with decarboxylase inhibitor and COMT inhibitor	Dopamine pathway; COMT enzyme
sinemet plus	sinemet plus	Hospital de Granollers	marketed	Dopamine replacement therapy with COMT inhibitor	Dopamine pathway; COMT enzyme

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (COMT inhibitor class)

Orion Corporation, Orion Pharma · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Comtess® — Competitive Intelligence Brief. https://druglandscape.com/ci/comtess. Accessed 2026-05-13.

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