Who are Comparator: Sitagliptin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Sitagliptin combined with metformin, Dapagliflozin/Sitagliptin, Teneli (Teneligliptin), Januvia (sitagliptin), alogliptin + pioglitazone, Metformin plus vildagliptin.

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Last reviewed 2026-06-10 · How we verify

Comparator: Sitagliptin — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparator: Sitagliptin (Comparator: Sitagliptin) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: DPP-4 inhibitor. Area: Diabetes.

phase 3 DPP-4 inhibitor DPP-4 (dipeptidyl peptidase-4) Diabetes Small molecule Live · refreshed every 30 min

Target snapshot

Comparator: Sitagliptin (Comparator: Sitagliptin) — Merck Sharp & Dohme LLC. Sitagliptin inhibits dipeptidyl peptidase-4 (DPP-4), prolonging the activity of incretin hormones to increase insulin secretion and decrease glucagon in response to meals.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Comparator: Sitagliptin TARGET	Comparator: Sitagliptin	Merck Sharp & Dohme LLC	phase 3	DPP-4 inhibitor	DPP-4 (dipeptidyl peptidase-4)
Sitagliptin combined with metformin	Sitagliptin combined with metformin	Sun Yat-sen University	marketed	DPP-4 inhibitor combined with biguanide	DPP-4 enzyme; metformin acts on multiple targets including mitochondrial complex I
Dapagliflozin/Sitagliptin	Dapagliflozin/Sitagliptin	Boryung Pharmaceutical Co., Ltd	marketed	SGLT2 inhibitor / DPP-4 inhibitor combination	SGLT2 (sodium-glucose cotransporter 2) and DPP-4 (dipeptidyl peptidase-4)
Teneli (Teneligliptin)	Teneli (Teneligliptin)	Tanabe Pharma Corporation	marketed	DPP-4 inhibitor	DPP-4 (Dipeptidyl peptidase-4)
Januvia (sitagliptin)	Januvia (sitagliptin)	Zealand University Hospital	marketed	DPP-4 inhibitor	DPP-4 (dipeptidyl peptidase-4)
alogliptin + pioglitazone	alogliptin + pioglitazone	Kun-Ho Yoon	marketed	DPP-4 inhibitor + thiazolidinedione	DPP-4 and PPAR-γ
Metformin plus vildagliptin	Metformin plus vildagliptin	Sheba Medical Center	marketed	Biguanide + DPP-4 inhibitor combination	Metformin: mitochondrial glycerophosphate dehydrogenase; Vildagliptin: DPP-4 (dipeptidyl peptidase-4)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (DPP-4 inhibitor class)

Merck Sharp & Dohme LLC · 5 drugs in this class
Daewoong Pharmaceutical Co. LTD. · 4 drugs in this class
AstraZeneca · 4 drugs in this class
LG Life Sciences · 2 drugs in this class
Tanabe Pharma Corporation · 2 drugs in this class
Ain Shams University · 2 drugs in this class
Ono Pharmaceutical Co. Ltd · 2 drugs in this class
Cinnagen · 1 drug in this class
GRADE Study Group · 1 drug in this class
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Comparator: Sitagliptin — Competitive Intelligence Brief. https://druglandscape.com/ci/comparator-sitagliptin. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing