Who are CI-581-a's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Namenda, Felbatol, QUINIDINE, Methadone Hydrochloride, Oxygen/nitrous oxide equimolar mix, diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan.

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Last reviewed 2026-05-14 · How we verify

CI-581-a — Competitive Intelligence Brief

CI-581-a (CI-581-a) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: NMDA receptor antagonist / Dissociative anesthetic. Area: Anesthesia / Psychiatry.

phase 3 NMDA receptor antagonist / Dissociative anesthetic NMDA receptor Anesthesia / Psychiatry Small molecule Live · refreshed every 30 min

Target snapshot

CI-581-a (CI-581-a) — New York State Psychiatric Institute. CI-581-a is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset anesthesia and analgesia.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
CI-581-a TARGET	CI-581-a	New York State Psychiatric Institute	phase 3	NMDA receptor antagonist / Dissociative anesthetic	NMDA receptor
Namenda	MEMANTINE	AbbVie	marketed	N-methyl-D-aspartate Receptor Antagonist	Glutamate NMDA receptor; GRIN1/GRIN2A	2003-01-01
Felbatol	FELBAMATE	Mylan Speciality Lp	marketed	Anti-epileptic Agent [EPC]	NMDA receptor-ionophore complex	1993-01-01
QUINIDINE	QUINIDINE		marketed		sigma-1 receptor, NMDA receptor, CYP2D6	1950-01-01
Methadone Hydrochloride	METHADONE	Specgx Llc	marketed	Opioid Agonist	mu-opioid receptors, NMDA receptor	1947-01-01
Oxygen/nitrous oxide equimolar mix	Oxygen/nitrous oxide equimolar mix	Hospital St. Joseph, Marseille, France	marketed	Inhalational anesthetic/analgesic gas mixture	NMDA receptor antagonist; endogenous opioid system modulation
diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan	diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan	Montefiore Medical Center	marketed	Combination cold/cough/allergy remedy	H1 histamine receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); NMDA receptor and sigma-1 receptor (dextromethorphan)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (NMDA receptor antagonist / Dissociative anesthetic class)

New York State Psychiatric Institute · 2 drugs in this class
Ullevaal University Hospital · 1 drug in this class

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Cite this brief

Drug Landscape (2026). CI-581-a — Competitive Intelligence Brief. https://druglandscape.com/ci/ci-581-a. Accessed 2026-05-14.

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