Chloroquine (CQ) — Competitive Intelligence Brief

Chloroquine (CQ) (Chloroquine (CQ)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Quinoline antimalarial. Area: Infectious Disease; Rheumatology.

marketed Quinoline antimalarial Heme; Toll-like receptors (immunomodulatory effects) Infectious Disease; Rheumatology Small molecule

Target snapshot

Chloroquine (CQ) (Chloroquine (CQ)) — London School of Hygiene and Tropical Medicine. Chloroquine is a quinoline antimalarial that accumulates in parasitic food vacuoles and inhibits heme polymerization, causing toxic heme accumulation and parasite death.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Chloroquine (CQ) TARGET	Chloroquine (CQ)	London School of Hygiene and Tropical Medicine	marketed	Quinoline antimalarial	Heme; Toll-like receptors (immunomodulatory effects)
Supervised primaquine treatment	Supervised primaquine treatment	Menzies School of Health Research	marketed	8-aminoquinoline antimalarial	Plasmodium parasite mitochondria and DNA
artesunate-amodiaquine (AS-AQ)	artesunate-amodiaquine (AS-AQ)	Yale University	marketed	Artemisinin derivative + aminoquinoline antimalarial combination	Plasmodium falciparum heme iron (Fe2+), parasite DNA, heme polymerase
Unsupervised primaquine treatment	Unsupervised primaquine treatment	Menzies School of Health Research	marketed	8-aminoquinoline antimalarial	Malaria parasite mitochondria and DNA (indirect via oxidative stress)
Hydroxychloroquine Sulfate Regular dose	Hydroxychloroquine Sulfate Regular dose	Government of Punjab, Specialized Healthcare and Medical Education Department	marketed	Quinoline antimalarial and immunomodulator	Lysosomal pH regulation; toll-like receptors (indirect)
PQ supervised	PQ supervised	Menzies School of Health Research	marketed	8-aminoquinoline antimalarial	Plasmodium hypnozoites (mechanism not fully elucidated at molecular level)
Chloroquine profilaxis	Chloroquine profilaxis	Institut de Recherche pour le Developpement	marketed	Quinoline antimalarial	Plasmodium heme detoxification pathway; DNA/RNA synthesis

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Quinoline antimalarial class)

1. Institut de Recherche pour le Developpement · 1 drug in this class
2. London School of Hygiene and Tropical Medicine · 1 drug in this class