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artesunate-amodiaquine (AS-AQ)
artesunate-amodiaquine (AS-AQ) is a Artemisinin derivative + aminoquinoline antimalarial combination Small molecule drug developed by Yale University. It is currently FDA-approved for Treatment of acute, uncomplicated Plasmodium falciparum malaria.
Artesunate-amodiaquine (AS-AQ), developed by Yale University, is a marketed combination therapy for the treatment of acute, uncomplicated Plasmodium falciparum malaria. Its key strength lies in the rapid parasite killing action of artesunate combined with the sustained suppression from amodiaquine, making it effective in regions where this type of malaria is prevalent. The primary risk is the presence of strong competitors such as Artemether–Lumefantrine (AL) and Dihydroartemisinin–Piperaquine (DP), both of which offer high efficacy and safety, potentially limiting AS-AQ's market share.
At a glance
| Generic name | artesunate-amodiaquine (AS-AQ) |
|---|---|
| Sponsor | Yale University |
| Drug class | Artemisinin derivative + aminoquinoline antimalarial combination |
| Target | Plasmodium falciparum heme iron (Fe2+), parasite DNA, heme polymerase |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | FDA-approved |
Approved indications
- Treatment of acute, uncomplicated Plasmodium falciparum malaria
Common side effects
Drug interactions
- Rifampin
- Ketoconazole
- CYP3A4 inhibitors
- CYP3A4 inducers
- Antacids
Key clinical trials
- OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa (PHASE4)
- Health Systems Implementation and Molecular Surveillance of Multiple First-Line Treatments for Uncomplicated Malaria in Western Kenya
- A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs. (PHASE3)
- In Vivo Efficacy of Artemether-Lumefantrine, Amodiaquine-Artesunate, Dihydroartemisinin-Piperaquine, and Pironaridine-Artesunate in Mozambique (PHASE4)
- Parasite Clearance and Protection from Infection (PCPI) in Cameroon (PHASE3)
- Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial (PHASE2, PHASE3)
- Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali (PHASE2)
- Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- artesunate-amodiaquine (AS-AQ) CI brief — competitive landscape report
- artesunate-amodiaquine (AS-AQ) updates RSS · CI watch RSS
- Yale University portfolio CI
Frequently asked questions about artesunate-amodiaquine (AS-AQ)
What is artesunate-amodiaquine (AS-AQ)?
What is artesunate-amodiaquine (AS-AQ) used for?
Who makes artesunate-amodiaquine (AS-AQ)?
What drug class is artesunate-amodiaquine (AS-AQ) in?
What development phase is artesunate-amodiaquine (AS-AQ) in?
What does artesunate-amodiaquine (AS-AQ) target?
Related
- Drug class: All Artemisinin derivative + aminoquinoline antimalarial combination drugs
- Target: All drugs targeting Plasmodium falciparum heme iron (Fe2+), parasite DNA, heme polymerase
- Manufacturer: Yale University — full pipeline
- Therapeutic area: All drugs in Neuroscience
- Indication: Drugs for Treatment of acute, uncomplicated Plasmodium falciparum malaria
- Compare: artesunate-amodiaquine (AS-AQ) vs similar drugs
- Pricing: artesunate-amodiaquine (AS-AQ) cost, discount & access