Who are CFTR modulators's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Symdeko (Copackaged), Ivacaftor+lumacaftor, SUZ, LUM/IVA, Initiation of CFTR Modulator, IVA.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-06-10 · How we verify

CFTR modulators — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

CFTR modulators (CFTR modulators) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: CFTR modulator. Area: Respiratory.

phase 2 CFTR modulator CFTR Respiratory Small molecule Live · refreshed every 30 min

Target snapshot

CFTR modulators (CFTR modulators) — Hospices Civils de Lyon. CFTR modulators work by modifying the cystic fibrosis transmembrane conductance regulator protein to restore normal chloride ion transport across epithelial cell membranes.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
CFTR modulators TARGET	CFTR modulators	Hospices Civils de Lyon	phase 2	CFTR modulator	CFTR
Symdeko (Copackaged)	TEZACAFTOR	Vertex Pharms	marketed		CFTR	2018-01-01
Ivacaftor+lumacaftor	Ivacaftor+lumacaftor	Assistance Publique - Hôpitaux de Paris	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
SUZ	SUZ	Vertex Pharmaceuticals Incorporated	marketed	CFTR potentiator	CFTR (cystic fibrosis transmembrane conductance regulator)
LUM/IVA	LUM/IVA	Vertex Pharmaceuticals Incorporated	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Initiation of CFTR Modulator	Initiation of CFTR Modulator	Children's Hospital Medical Center, Cincinnati	marketed	CFTR modulator	CFTR (cystic fibrosis transmembrane conductance regulator)
IVA	IVA	Vertex Pharmaceuticals Incorporated	marketed	CFTR potentiator	CFTR (cystic fibrosis transmembrane conductance regulator)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2026-07-06 — Symdeko (Copackaged) · 8354427 · US
2026-12-28 — Symdeko (Copackaged) · 9931334 · US
2026-12-28 — Symdeko (Copackaged) · 9670163 · US
2026-12-28 — Symdeko (Copackaged) · 8754224 · US
2026-12-28 — Symdeko (Copackaged) · 8410274 · US
2027-04-09 — Symdeko (Copackaged) · 10239867 · US
2027-04-09 — Symdeko (Copackaged) · 9974781 · US
2027-04-09 — Symdeko (Copackaged) · 11639347 · US
2027-04-09 — Symdeko (Copackaged) · 10022352 · US
2027-05-01 — Symdeko (Copackaged) · 8598181 · US
2027-05-01 — Symdeko (Copackaged) · 7645789 · US
2027-05-01 — Symdeko (Copackaged) · 8623905 · US
2027-05-20 — Symdeko (Copackaged) · 7495103 · US
2027-06-03 — Symdeko (Copackaged) · 7776905 · US
2027-08-05 — Symdeko (Copackaged) · 8324242 · US
2027-11-12 — Symdeko (Copackaged) · 8415387 · US
2029-08-13 — Symdeko (Copackaged) · 11564916 · US
2029-08-13 — Symdeko (Copackaged) · 10646481 · US
2031-03-25 — Symdeko (Copackaged) · 10081621 · US
2031-03-25 — Symdeko (Copackaged) · 11578062 · US
2033-07-15 — Symdeko (Copackaged) · 10058546 · US
2033-07-15 — Symdeko (Copackaged) · 9012496 · US
2035-04-14 — Symdeko (Copackaged) · 10206877 · US

Sponsor landscape (CFTR modulator class)

Vertex Pharmaceuticals Incorporated · 5 drugs in this class
Chiesi Farmaceutici S.p.A. · 1 drug in this class
Children's Hospital Medical Center, Cincinnati · 1 drug in this class
Hospices Civils de Lyon · 1 drug in this class

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Cite this brief

Drug Landscape (2026). CFTR modulators — Competitive Intelligence Brief. https://druglandscape.com/ci/cftr-modulators. Accessed 2026-06-10.

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