Who are Cetirizine (Zyrtec)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lastacaft, Xyzal, Elestat, Rupax, Zaditor, Mizollen.

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Last reviewed 2026-05-16 · How we verify

Cetirizine (Zyrtec) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cetirizine (Zyrtec) (Cetirizine (Zyrtec)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: H1-receptor antagonist (second-generation antihistamine). Area: Immunology / Allergy.

marketed H1-receptor antagonist (second-generation antihistamine) H1 receptor Immunology / Allergy Small molecule Live · refreshed every 30 min

Target snapshot

Cetirizine (Zyrtec) (Cetirizine (Zyrtec)) — Organon and Co. Cetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on cells, preventing allergic symptoms.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Cetirizine (Zyrtec) TARGET	Cetirizine (Zyrtec)	Organon and Co	marketed	H1-receptor antagonist (second-generation antihistamine)	H1 receptor
Lastacaft	ALCAFTADINE	AbbVie	marketed	Histamine-1 Receptor Antagonist [EPC]	Histamine H1 receptor	2010-01-01
Xyzal	LEVOCETIRIZINE	Sanofi	marketed	Histamine-1 Receptor Antagonist	Histamine H1 receptor	2007-01-01
Elestat	EPINASTINE	AbbVie	marketed	Adrenergic Receptor Agonist	Histamine H1 receptor	2003-01-01
Rupax	RUPATADINE	Teikoku Seiyaku	marketed	rupatadine	Histamine H1 receptor	2001-01-01
Zaditor	KETOTIFEN		marketed	Histamine-1 Receptor Inhibitor	Histamine H1 receptor	1999-01-01
Mizollen	MIZOLASTINE	Sanofi	marketed	mizolastine	Histamine H1 receptor	1998-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (H1-receptor antagonist (second-generation antihistamine) class)

UCB Pharma · 5 drugs in this class
Organon and Co · 3 drugs in this class
Brian J Lipworth · 1 drug in this class
GlaxoSmithKline · 1 drug in this class
Goldman, Butterwick, Fitzpatrick and Groff · 1 drug in this class
HK inno.N Corporation · 1 drug in this class
AAADRS Clinical Research Center · 1 drug in this class
University Hospital, Grenoble · 1 drug in this class
Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Cetirizine (Zyrtec) — Competitive Intelligence Brief. https://druglandscape.com/ci/cetirizine-zyrtec. Accessed 2026-05-16.

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