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BT5528 — Competitive Intelligence Brief
phase 2
CD47/SIRPα inhibitor
CD47
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
BT5528 (BT5528) — BicycleTx Limited. BT5528 is a small molecule inhibitor of the CD47/SIRPα axis.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| BT5528 TARGET | BT5528 | BicycleTx Limited | phase 2 | CD47/SIRPα inhibitor | CD47 | |
| mini CYVE, without 3 maintenance courses | mini CYVE, without 3 maintenance courses | Gustave Roussy, Cancer Campus, Grand Paris | phase 3 | CD47/SIRPα inhibitor | CD47 | |
| MB-102 DMID | MB-102 DMID | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | phase 3 | monoclonal antibody | CD47 | |
| MB-102 OMID | MB-102 OMID | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | phase 3 | CD47 inhibitor | CD47 | |
| [68Ga]Ga-PentixaFor | [68Ga]Ga-PentixaFor | Nantes University Hospital | phase 3 | Radiopharmaceutical | CD47 | |
| Open single period A140 | Open single period A140 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | phase 3 | CD47 inhibitor | CD47 | |
| Treatment Choice (TC) | Treatment Choice (TC) | Astex Pharmaceuticals, Inc. | phase 3 | SIRPα inhibitor | CD47 |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (CD47/SIRPα inhibitor class)
- BicycleTx Limited · 1 drug in this class
- Gustave Roussy, Cancer Campus, Grand Paris · 1 drug in this class
- Jiangsu HengRui Medicine Co., Ltd. · 1 drug in this class
- Kuhnil Pharmaceutical Co., Ltd. · 1 drug in this class
- Merck KGaA, Darmstadt, Germany · 1 drug in this class
- Pharmicell Co., Ltd. · 1 drug in this class
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- BT5528 CI watch — RSS
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- Whole CD47/SIRPα inhibitor class — RSS
Cite this brief
Drug Landscape (2026). BT5528 — Competitive Intelligence Brief. https://druglandscape.com/ci/bt5528. Accessed 2026-06-10.
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