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Brivanib 800 mg, QD — Competitive Intelligence Brief
phase 2
Dual FGFR/VEGFR inhibitor
FGFR, VEGFR
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Brivanib 800 mg, QD (Brivanib 800 mg, QD) — Zai Lab (Shanghai) Co., Ltd.. Brivanib is a dual inhibitor of fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) that blocks angiogenesis and tumor cell proliferation.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Brivanib 800 mg, QD TARGET | Brivanib 800 mg, QD | Zai Lab (Shanghai) Co., Ltd. | phase 2 | Dual FGFR/VEGFR inhibitor | FGFR, VEGFR | |
| pirfenidone or nintedanib | pirfenidone or nintedanib | Hospices Civils de Lyon | marketed | Antifibrotic agent | Pirfenidone: TGF-β pathway; Nintedanib: FGFR, VEGFR, PDGFR tyrosine kinases | |
| Lenvatinib + losartan | Lenvatinib + losartan | Second Affiliated Hospital of Xi'an Jiaotong University | marketed | Multi-targeted tyrosine kinase inhibitor + angiotensin II receptor antagonist | FGFR, VEGFR, RET (lenvatinib); AT1 receptor (losartan) | |
| AL3818 Capsule | AL3818 Capsule | Advenchen Laboratories Nanjing Ltd. | phase 3 | Multi-targeted tyrosine kinase inhibitor | FGFR, VEGFR, and other receptor tyrosine kinases | |
| Len-TACE | Len-TACE | Second Affiliated Hospital of Guangzhou Medical University | phase 3 | Multi-kinase inhibitor (combined with transarterial chemoembolization) | FGFR, VEGFR, RET, KIT | |
| Adjuvant tislelizumab plus lenvatinib | Adjuvant tislelizumab plus lenvatinib | Guangxi Medical University | phase 3 | PD-1 inhibitor + multi-targeted tyrosine kinase inhibitor combination | PD-1 (tislelizumab); FGFR, VEGFR, RET, KIT (lenvatinib) | |
| Lenvatinib, sintilimab plus TACE | Lenvatinib, sintilimab plus TACE | Second Affiliated Hospital of Guangzhou Medical University | phase 3 | Multi-kinase inhibitor + PD-1 inhibitor + locoregional chemotherapy | FGFR, VEGFR, RET, KIT (lenvatinib); PD-1 (sintilimab) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Dual FGFR/VEGFR inhibitor class)
- Zai Lab (Shanghai) Co., Ltd. · 2 drugs in this class
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Cite this brief
Drug Landscape (2026). Brivanib 800 mg, QD — Competitive Intelligence Brief. https://druglandscape.com/ci/brivanib-800-mg-qd. Accessed 2026-05-17.
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