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Brimonidine 0.33% gel (Br) — Competitive Intelligence Brief
marketed
Alpha-2 adrenergic agonist
Alpha-2 adrenergic receptor
Dermatology
Small molecule
Live · refreshed every 30 min
Target snapshot
Brimonidine 0.33% gel (Br) (Brimonidine 0.33% gel (Br)) — Galderma R&D. Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness in the skin.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Brimonidine 0.33% gel (Br) TARGET | Brimonidine 0.33% gel (Br) | Galderma R&D | marketed | Alpha-2 adrenergic agonist | Alpha-2 adrenergic receptor | |
| Dexmetomidine intravenously | Dexmetomidine intravenously | KAT General Hospital | marketed | Alpha-2 adrenergic receptor agonist | Alpha-2 adrenergic receptor | |
| lofexidine HCl | lofexidine HCl | USWM, LLC (dba US WorldMeds) | marketed | Alpha-2 adrenergic agonist | Alpha-2 adrenergic receptor | |
| Intranasal dexmedetomidine-esketamine | Intranasal dexmedetomidine-esketamine | Peking University First Hospital | marketed | Alpha-2 adrenergic agonist / NMDA receptor antagonist combination | Alpha-2 adrenergic receptors; NMDA receptor | |
| Combigan Two Times Daily (BID) | Combigan Two Times Daily (BID) | Cornerstone Health Care, PA | marketed | Fixed-dose combination of alpha-2 adrenergic agonist and beta-blocker | Alpha-2 adrenergic receptor; beta-1 and beta-2 adrenergic receptors | |
| Sufentanil and dexmedetomidine | Sufentanil and dexmedetomidine | Obstetrics & Gynecology Hospital of Fudan University | marketed | Opioid agonist and alpha-2 adrenergic agonist combination | Mu opioid receptor and alpha-2 adrenergic receptor | |
| Dexmedetomidine-esketamine combination | Dexmedetomidine-esketamine combination | Peking University First Hospital | marketed | Sedative-analgesic combination | Alpha-2 adrenergic receptor; NMDA receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Alpha-2 adrenergic agonist class)
- USWM, LLC (dba US WorldMeds) · 2 drugs in this class
- China International Neuroscience Institution · 1 drug in this class
- Icahn School of Medicine at Mount Sinai · 1 drug in this class
- Eye Therapies, LLC · 1 drug in this class
- Galderma R&D · 1 drug in this class
- Guangzhou Women and Children's Medical Center · 1 drug in this class
- Derm Research, PLLC · 1 drug in this class
- Irmandade da Santa Casa de Misericordia de Sao Paulo · 1 drug in this class
- KK Women's and Children's Hospital · 1 drug in this class
- American University of Beirut Medical Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Brimonidine 0.33% gel (Br) — Competitive Intelligence Brief. https://druglandscape.com/ci/brimonidine-0-33-gel-br. Accessed 2026-05-16.
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