bevacizumab plus chemotherapy — Competitive Intelligence Brief

bevacizumab plus chemotherapy (bevacizumab plus chemotherapy) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Angiogenesis inhibitor. Area: Oncology.

phase 3 Angiogenesis inhibitor VEGF-A Oncology Small molecule

Target snapshot

bevacizumab plus chemotherapy (bevacizumab plus chemotherapy) — Liaoning Cancer Hospital & Institute. Bevacizumab is a monoclonal antibody that inhibits angiogenesis by binding to vascular endothelial growth factor A (VEGF-A), thereby preventing tumor growth and metastasis.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
bevacizumab plus chemotherapy TARGET	bevacizumab plus chemotherapy	Liaoning Cancer Hospital & Institute	phase 3	Angiogenesis inhibitor	VEGF-A
Lucentis every 12 weeks	Lucentis every 12 weeks	Retinal Consultants of Arizona	marketed	VEGF-A inhibitor (monoclonal antibody fragment)	VEGF-A
Ziv aflibercept	Ziv aflibercept	Marashi Eye Clinic	marketed	VEGF inhibitor / Antiangiogenic agent	VEGF-A, VEGF-B, PlGF (Placental Growth Factor)
Lucentis (Treat and extend)	Lucentis (Treat and extend)	Retinal Consultants of Arizona	marketed	VEGF inhibitor (monoclonal antibody fragment)	VEGF-A
Lucentis every 4 weeks	Lucentis every 4 weeks	Retinal Consultants of Arizona	marketed	VEGF-A inhibitor (monoclonal antibody fragment)	VEGF-A
Aflibercept Intravitreous Injection	Aflibercept Intravitreous Injection	Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine	marketed	VEGF inhibitor / Soluble decoy receptor	VEGF-A, VEGF-B, PlGF (placental growth factor)
Ranibizumab and Aflibercept	Ranibizumab and Aflibercept	Instituto de Olhos de Goiania	marketed	Anti-VEGF agent	VEGF-A (vascular endothelial growth factor-A)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Angiogenesis inhibitor class)

1. Jiangsu Simcere Pharmaceutical Co., Ltd. · 3 drugs in this class
2. Eli Lilly and Company · 1 drug in this class
3. Guangzhou Institute of Respiratory Disease · 1 drug in this class
4. Hoffmann-La Roche · 1 drug in this class
5. Liaoning Cancer Hospital & Institute · 1 drug in this class
6. PPD Development, LP · 1 drug in this class
7. Peking University Cancer Hospital & Institute · 1 drug in this class
8. Sanofi · 1 drug in this class
9. ARCAGY/ GINECO GROUP · 1 drug in this class
10. Second Affiliated Hospital of Xi'an Jiaotong University · 1 drug in this class