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Aprepitant+palonosetron+dexamethasone — Competitive Intelligence Brief
phase 3
Antiemetic combination (NK1 antagonist + 5-HT3 antagonist + corticosteroid)
NK1 receptor, 5-HT3 receptor, glucocorticoid receptor
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Aprepitant+palonosetron+dexamethasone (Aprepitant+palonosetron+dexamethasone) — Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. This combination blocks chemotherapy-induced nausea and vomiting (CINV) through three complementary pathways: NK1 receptor antagonism, 5-HT3 receptor antagonism, and glucocorticoid anti-inflammatory effects.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Aprepitant+palonosetron+dexamethasone TARGET | Aprepitant+palonosetron+dexamethasone | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | phase 3 | Antiemetic combination (NK1 antagonist + 5-HT3 antagonist + corticosteroid) | NK1 receptor, 5-HT3 receptor, glucocorticoid receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antiemetic combination (NK1 antagonist + 5-HT3 antagonist + corticosteroid) class)
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Aprepitant+palonosetron+dexamethasone — Competitive Intelligence Brief. https://druglandscape.com/ci/aprepitant-palonosetron-dexamethasone. Accessed 2026-05-17.
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