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Amitriptyline plus Fluoxitine — Competitive Intelligence Brief
marketed
Antidepressant combination (tricyclic antidepressant + SSRI)
Serotonin transporter (SERT), norepinephrine transporter (NET)
Psychiatry/Mental Health
Small molecule
Live · refreshed every 30 min
Target snapshot
Amitriptyline plus Fluoxitine (Amitriptyline plus Fluoxitine) — Tufts Medical Center. This combination increases serotonin availability in the brain through dual mechanisms: amitriptyline blocks serotonin and norepinephrine reuptake, while fluoxetine selectively inhibits serotonin reuptake.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Amitriptyline plus Fluoxitine TARGET | Amitriptyline plus Fluoxitine | Tufts Medical Center | marketed | Antidepressant combination (tricyclic antidepressant + SSRI) | Serotonin transporter (SERT), norepinephrine transporter (NET) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antidepressant combination (tricyclic antidepressant + SSRI) class)
- Tufts Medical Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Amitriptyline plus Fluoxitine — Competitive Intelligence Brief. https://druglandscape.com/ci/amitriptyline-plus-fluoxitine. Accessed 2026-05-14.
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