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Ambrisentan plus Spironolactone — Competitive Intelligence Brief

Ambrisentan plus Spironolactone (Ambrisentan plus Spironolactone) competitive landscape: 0 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Endothelin receptor antagonist + Mineralocorticoid receptor antagonist combination. Area: Cardiovascular.

marketed Endothelin receptor antagonist + Mineralocorticoid receptor antagonist combination Endothelin-1 receptor (ETA/ETB) + Mineralocorticoid receptor Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Ambrisentan plus Spironolactone (Ambrisentan plus Spironolactone) — Brigham and Women's Hospital. Ambrisentan blocks endothelin-1 receptors to reduce pulmonary vascular resistance, while spironolactone is a mineralocorticoid receptor antagonist that provides additional hemodynamic and anti-fibrotic benefits.

Comparator set

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Ambrisentan plus Spironolactone TARGET Ambrisentan plus Spironolactone Brigham and Women's Hospital marketed Endothelin receptor antagonist + Mineralocorticoid receptor antagonist combination Endothelin-1 receptor (ETA/ETB) + Mineralocorticoid receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Endothelin receptor antagonist + Mineralocorticoid receptor antagonist combination class)

  1. Brigham and Women's Hospital · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Ambrisentan plus Spironolactone — Competitive Intelligence Brief. https://druglandscape.com/ci/ambrisentan-plus-spironolactone. Accessed 2026-05-16.

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