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Ambrisentan plus Spironolactone — Competitive Intelligence Brief
marketed
Endothelin receptor antagonist + Mineralocorticoid receptor antagonist combination
Endothelin-1 receptor (ETA/ETB) + Mineralocorticoid receptor
Cardiovascular
Small molecule
Live · refreshed every 30 min
Target snapshot
Ambrisentan plus Spironolactone (Ambrisentan plus Spironolactone) — Brigham and Women's Hospital. Ambrisentan blocks endothelin-1 receptors to reduce pulmonary vascular resistance, while spironolactone is a mineralocorticoid receptor antagonist that provides additional hemodynamic and anti-fibrotic benefits.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Ambrisentan plus Spironolactone TARGET | Ambrisentan plus Spironolactone | Brigham and Women's Hospital | marketed | Endothelin receptor antagonist + Mineralocorticoid receptor antagonist combination | Endothelin-1 receptor (ETA/ETB) + Mineralocorticoid receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Endothelin receptor antagonist + Mineralocorticoid receptor antagonist combination class)
- Brigham and Women's Hospital · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Ambrisentan plus Spironolactone — Competitive Intelligence Brief. https://druglandscape.com/ci/ambrisentan-plus-spironolactone. Accessed 2026-05-16.
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