Who are Alvelestat oral tablet - dose 1's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Alpha1-Proteinase Inhibitor, Alpha 1-Antitrypsin, alpha-1-Proteinase Inhibitor, Aralast NP, Alpha-1 antitrypsin (AAT), NRL972.

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Last reviewed 2026-05-17 · How we verify

Alvelestat oral tablet - dose 1 — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Alvelestat oral tablet - dose 1 (Alvelestat oral tablet - dose 1) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Neutrophil elastase inhibitor. Area: Respiratory.

phase 2 Neutrophil elastase inhibitor Neutrophil elastase Respiratory Small molecule Live · refreshed every 30 min

Target snapshot

Alvelestat oral tablet - dose 1 (Alvelestat oral tablet - dose 1) — Mereo BioPharma. Alvelestat is a selective inhibitor of neutrophil elastase, an enzyme involved in the degradation of lung tissue.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Alvelestat oral tablet - dose 1 TARGET	Alvelestat oral tablet - dose 1	Mereo BioPharma	phase 2	Neutrophil elastase inhibitor	Neutrophil elastase
Alpha1-Proteinase Inhibitor	Alpha1-Proteinase Inhibitor	Baxalta now part of Shire	marketed	Protease inhibitor (protein replacement therapy)	Neutrophil elastase (indirect target via AAT inhibition)
Alpha 1-Antitrypsin	Alpha 1-Antitrypsin	University of Minnesota	marketed	Protease inhibitor; protein replacement therapy	Neutrophil elastase
alpha-1-Proteinase Inhibitor	alpha-1-Proteinase Inhibitor	Institute for Human Genetics and Biochemistry	marketed	Protease inhibitor / Enzyme replacement therapy	Neutrophil elastase
Aralast NP	Aralast NP	National Institute of Allergy and Infectious Diseases (NIAID)	marketed	Protease inhibitor (augmentation therapy)	Alpha-1 protease inhibitor (AAT); neutrophil elastase inhibition
Alpha-1 antitrypsin (AAT)	Alpha-1 antitrypsin (AAT)	CSL Behring	phase 3	Protease inhibitor / Protein replacement therapy	Neutrophil elastase
NRL972	NRL972	Norgine	phase 3	Neutrophil elastase inhibitor	Neutrophil elastase (NE)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Neutrophil elastase inhibitor class)

Mereo BioPharma · 1 drug in this class
Norgine · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Alvelestat oral tablet - dose 1 — Competitive Intelligence Brief. https://druglandscape.com/ci/alvelestat-oral-tablet-dose-1. Accessed 2026-05-17.

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