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Aldoxorubicin HCl — Competitive Intelligence Brief
phase 2
antitumor antibiotic
DNA topoisomerase II
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Aldoxorubicin HCl (Aldoxorubicin HCl) — ImmunityBio, Inc.. Aldoxorubicin HCl is a prodrug that selectively releases doxorubicin in acidic environments, such as tumor cells, to exert its cytotoxic effects.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Aldoxorubicin HCl TARGET | Aldoxorubicin HCl | ImmunityBio, Inc. | phase 2 | antitumor antibiotic | DNA topoisomerase II | |
| Cipro | ciprofloxacin | Bayer AG | marketed | Fluoroquinolone antibiotic | DNA topoisomerase II, DNA gyrase subunit A, DNA gyrase subunit A | 1987-10-22 |
| Amekrin | AMSACRINE | marketed | amsacrine | DNA topoisomerase 2-beta, Solute carrier family 22 member 1, DNA topoisomerase II | 1987-01-01 | |
| Doxorubicin hydrochloride liposome | Doxorubicin hydrochloride liposome | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | marketed | Anthracycline chemotherapy agent (liposomal formulation) | DNA topoisomerase II | |
| Liposome doxorubicin | Liposome doxorubicin | Sun Yat-sen University | marketed | Liposomal chemotherapy; topoisomerase II inhibitor | DNA topoisomerase II | |
| Doxorubicin Hydrochloride | Doxorubicin Hydrochloride | Pfizer Inc. | marketed | Anthracycline topoisomerase inhibitor | DNA topoisomerase II, nucleotide bases | |
| aclacinomycin | aclacinomycin | Chinese PLA General Hospital | phase 3 | 72 kDa type IV collagenase, DNA topoisomerase II, 5-hydroxytryptamine receptor 2B |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
- — Cipro · 11369566 · Formulation · US
- — Cipro · 9603796 · Compound · US
- — Cipro · 9205048 · Method of Use · US
- — Cipro · 9233068 · Formulation · US
- — Cipro · 8318817 · Method of Use · US
- — Cipro · 9220796 · Formulation · US
- — Cipro · 11040004 · Method of Use · US
- — Cipro · 11246863 · Formulation · US
Sponsor landscape (antitumor antibiotic class)
- ImmunityBio, Inc. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Aldoxorubicin HCl — Competitive Intelligence Brief. https://druglandscape.com/ci/aldoxorubicin-hcl. Accessed 2026-05-18.
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