Who are AKR1C3-activated Prodrug AST-3424's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): tegafur-uracil, LDX Treatment, Vyvanse (lisdexamphetamine), Veklury, Tegafur-Ugotex or Capecitabine, TZP-101.

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Last reviewed 2026-05-17 · How we verify

AKR1C3-activated Prodrug AST-3424 — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

AKR1C3-activated Prodrug AST-3424 (AKR1C3-activated Prodrug AST-3424) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Prodrug. Area: Oncology.

phase 1 Prodrug AKR1C3 Oncology Small molecule Live · refreshed every 30 min

Target snapshot

AKR1C3-activated Prodrug AST-3424 (AKR1C3-activated Prodrug AST-3424) — SWOG Cancer Research Network. Activates AKR1C3

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
AKR1C3-activated Prodrug AST-3424 TARGET	AKR1C3-activated Prodrug AST-3424	SWOG Cancer Research Network	phase 1	Prodrug	AKR1C3
tegafur-uracil	tegafur-uracil	Yokohama City University	marketed	Antimetabolite; 5-fluorouracil prodrug	Thymidylate synthase
LDX Treatment	LDX Treatment	NYU Langone Health	marketed	Sympathomimetic amine; amphetamine prodrug	Norepinephrine transporter (NET); dopamine transporter (DAT)
Vyvanse (lisdexamphetamine)	Vyvanse (lisdexamphetamine)	Seattle Children's Hospital	marketed	Sympathomimetic amine; amphetamine prodrug	Norepinephrine transporter (NET); dopamine transporter (DAT)
Veklury	Veklury	ANRS, Emerging Infectious Diseases	marketed	Nucleoside analog prodrug	NS5, Replicase polyprotein 1ab
Tegafur-Ugotex or Capecitabine	Tegafur-Ugotex or Capecitabine	Liaoning Cancer Hospital & Institute	marketed	Antimetabolite; 5-fluorouracil prodrug	Thymidylate synthase
TZP-101	TZP-101	Tranzyme, Inc.	phase 3	Prodrug	H+/K+ ATPase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Prodrug class)

SWOG Cancer Research Network · 1 drug in this class
Tranzyme, Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). AKR1C3-activated Prodrug AST-3424 — Competitive Intelligence Brief. https://druglandscape.com/ci/akr1c3-activated-prodrug-ast-3424. Accessed 2026-05-17.

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