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Aczone Gel — Competitive Intelligence Brief
marketed
Sulfone antibiotic
Bacterial dihydropteroate synthase; neutrophil function modulation
Dermatology
Small molecule
Live · refreshed every 30 min
Target snapshot
Aczone Gel (Aczone Gel) — Icahn School of Medicine at Mount Sinai. Dapsone reduces inflammation and bacterial growth in acne lesions through its antimicrobial and anti-inflammatory properties.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Aczone Gel TARGET | Aczone Gel | Icahn School of Medicine at Mount Sinai | marketed | Sulfone antibiotic | Bacterial dihydropteroate synthase; neutrophil function modulation | |
| Dapsone 7.5 % gel | Dapsone 7.5 % gel | Derm Research, PLLC | marketed | Sulfone antibiotic with anti-inflammatory properties | Dihydropteroate synthase; neutrophil function and inflammatory mediators | |
| ACZONE Gel, 5% | ACZONE Gel, 5% | Allergan | marketed | Sulfone antibiotic | Bacterial dihydropteroate synthase; neutrophil-mediated inflammation | |
| Dapsone plus Adapalene | Dapsone plus Adapalene | Allergan | marketed | Retinoid plus sulfone antibiotic combination | Retinoic acid receptors (adapalene); dihydrofolate reductase inhibition and neutrophil suppression (dapsone) | |
| dapsone gel vehicle | dapsone gel vehicle | Almirall, S.A. | phase 3 | Sulfone antibiotic with anti-inflammatory properties | Dihydropteroate synthase; neutrophil function modulation | |
| Dapsone 5.0% Gel (SEEGPharm) | Dapsone 5.0% Gel (SEEGPharm) | Seegpharm S.A. | phase 3 | Sulfone antibiotic with anti-inflammatory properties | Dihydropteroate synthase (bacterial); neutrophil function and ROS production (host) | |
| Dapsone (Disulone®) | Dapsone (Disulone®) | Assistance Publique - Hôpitaux de Paris | phase 3 | Sulfone antibiotic with immunomodulatory properties | Dihydrofolate reductase; neutrophil function and complement pathway |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Sulfone antibiotic class)
- Allergan · 1 drug in this class
- Icahn School of Medicine at Mount Sinai · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Aczone Gel — Competitive Intelligence Brief. https://druglandscape.com/ci/aczone-gel. Accessed 2026-05-13.
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