Acetylcysteine (NAC) — Competitive Intelligence Brief

Acetylcysteine (NAC) (Acetylcysteine (NAC)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Mucolytic agent; antioxidant. Area: Respiratory; Toxicology; General Medicine.

marketed Mucolytic agent; antioxidant Glutathione synthesis; disulfide bonds in mucoproteins Respiratory; Toxicology; General Medicine Small molecule

Target snapshot

Acetylcysteine (NAC) (Acetylcysteine (NAC)) — Clinica Universidad de Navarra, Universidad de Navarra. Acetylcysteine is a mucolytic agent that breaks disulfide bonds in mucoproteins, reducing mucus viscosity and facilitating clearance, while also serving as a precursor to glutathione for antioxidant protection.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Acetylcysteine (NAC) TARGET	Acetylcysteine (NAC)	Clinica Universidad de Navarra, Universidad de Navarra	marketed	Mucolytic agent; antioxidant	Glutathione synthesis; disulfide bonds in mucoproteins
N-acetylcystein	N-acetylcystein	Assistance Publique - Hôpitaux de Paris	marketed	Antioxidant; mucolytic agent	Glutathione synthesis pathway; free radicals; mucus proteins
Mucolox® alone	Mucolox® alone	University of Alberta	marketed	Mucolytic agent
N-acetylcysteine	N-acetylcysteine	University of Turin, Italy	marketed	Antioxidant, mucolytic agent	Glutathione synthesis pathway; reactive oxygen species
NAC	NAC	Otologic Pharmaceutics, Inc.	marketed	Mucolytic agent and antioxidant	Disulfide bonds in mucoproteins; glutathione synthesis pathway
Hypertonic saline and epinephrine	Hypertonic saline and epinephrine	Le Bonheur Children's Hospital	marketed	Combination bronchodilator and mucolytic agent	Alpha-1 adrenergic receptors, beta-2 adrenergic receptors, osmotic gradient modulation
Ambroxol Hydrochloride	Ambroxol Hydrochloride	National University of Malaysia	marketed	Mucolytic agent

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Mucolytic agent; antioxidant class)

1. Clinica Universidad de Navarra, Universidad de Navarra · 1 drug in this class