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ABT-450/ritonavir — Competitive Intelligence Brief
phase 3
Hepatitis C virus NS3/4A protease inhibitor
HCV NS3/4A serine protease
Virology / Hepatology
Small molecule
Live · refreshed every 30 min
Target snapshot
ABT-450/ritonavir (ABT-450/ritonavir) — AbbVie (prior sponsor, Abbott). ABT-450 is a hepatitis C virus NS3/4A protease inhibitor that blocks viral replication, boosted by ritonavir to increase drug levels.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| ABT-450/ritonavir TARGET | ABT-450/ritonavir | AbbVie (prior sponsor, Abbott) | phase 3 | Hepatitis C virus NS3/4A protease inhibitor | HCV NS3/4A serine protease | |
| Daclatasvir plus Asunaprevir | Daclatasvir plus Asunaprevir | Myeong Jun Song | marketed | Direct-acting antiviral combination (NS5A inhibitor + NS3/4A protease inhibitor) | HCV NS5A protein and HCV NS3/4A serine protease | |
| Elbasvir/Grazoprevir | Elbasvir/Grazoprevir | University of Florence | marketed | Direct-acting antiviral (DAA) combination; NS5A inhibitor + NS3/4A protease inhibitor | HCV NS5A protein and HCV NS3/4A serine protease | |
| Elbasvir / Grazoprevir Oral Tablet [Zepatier] | Elbasvir / Grazoprevir Oral Tablet [Zepatier] | University of Maryland, Baltimore | marketed | Direct-acting antiviral (DAA) combination | HCV NS5A protein and HCV NS3/4A serine protease | |
| Viekira Pak ± ribavirin | Viekira Pak ± ribavirin | Massachusetts General Hospital | marketed | Direct-acting antiviral (DAA) combination | HCV NS5A protein, HCV NS3/4A serine protease | |
| ABT-450/r/ABT-267, ABT-333 | ABT-450/r/ABT-267, ABT-333 | AbbVie (prior sponsor, Abbott) | phase 3 | HCV protease inhibitor and non-nucleoside polymerase inhibitor combination | HCV NS3/4A serine protease and NS5B RNA-dependent RNA polymerase | |
| BMS-650032 (Asunaprevir) | BMS-650032 (Asunaprevir) | Bristol-Myers Squibb | phase 3 | HCV NS3 protease inhibitor | HCV NS3/4A serine protease |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Hepatitis C virus NS3/4A protease inhibitor class)
- AbbVie (prior sponsor, Abbott) · 1 drug in this class
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Cite this brief
Drug Landscape (2026). ABT-450/ritonavir — Competitive Intelligence Brief. https://druglandscape.com/ci/abt-450-ritonavir. Accessed 2026-05-17.
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