NCT07526649 (COOLHEAD-2B) is a NA clinical trial of Non-invasive convective head cooling in Stroke, sponsored by Auckland City Hospital.

Who is sponsoring NCT07526649?

NCT07526649 is sponsored by Auckland City Hospital.

What drugs are being tested in NCT07526649?

Interventions in NCT07526649: Non-invasive convective head cooling, Standard of Care (SOC).

What condition does NCT07526649 study?

NCT07526649 studies Stroke, Acute Ischemic Stroke, Brain Ischemia, Ischaemic Stroke, Thrombectomy, Endovascular Procedures, Reperfusion Injury, Cooling, Large Vessel Occlusion.

Is NCT07526649 still recruiting?

NCT07526649 is currently not yet recruiting. Last updated 13 April 2026.

Last reviewed 2026-04-13 · How we verify

NCT07526649: COOLHEAD-2B

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)

Not yet recruiting NA Last updated 13 April 2026

What this trial tests

NA trial testing Non-invasive convective head cooling in Stroke in 182 participants. Not yet recruiting.

Timeline

10 April 2026

Primary endpoint
31 December 2028

30 June 2029

Quick facts

Lead sponsor	Auckland City Hospital
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	182
Start date	10 April 2026
Primary completion	31 December 2028
Estimated completion	30 June 2029
Sites	1 location across New Zealand

Drugs / interventions tested

Non-invasive convective head cooling
Standard of Care (SOC) — full drug profile →

Conditions studied

Stroke — all drugs for Stroke →
Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →
Brain Ischemia — all drugs for Brain Ischemia →
Ischaemic Stroke — all drugs for Ischaemic Stroke →

Sponsor

Auckland City Hospital

Who can join

18 and older, any sex, with Stroke or Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

COOLHEAD-2b is a multicentre, phase 2, prospective, randomised, controlled, open-label, blinded-endpoint trial evaluating the safety and efficacy of non-invasive convective head cooling as an adjunct to endovascular thrombectomy (EVT) in patients with acute anterior circulation ischaemic stroke. Head cooling is initiated as early as possible, including during inter-hospital transfer, and continued until one hour after reperfusion. The primary efficacy endpoint is final infarct volume at 24 hours.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Other Auckland City Hospital trials

Trials by the same sponsor.

NCT06268080 — Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery · NA · recruiting
NCT04840316 — INcidence of PostOperative Delirium Incidence in Surgical Patients: an Observational Cohort Study in New Zealand · unknown
NCT05645861 — MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE · NA · active not recruiting
NCT02689388 — Evaluating the Addition of Regional Analgesia to Reduce Postoperative Delirium in Patients Having Hip Fracture Surgery. · NA · terminated
NCT04965324 — Depth of Anaesthesia and Long-term Survival: The Balanced Anaesthesia Follow-up Study · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07526649 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Auckland City Hospital
Last refreshed: 13 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07526649.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing