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NCT07525531: PRF-NSPT
Effects of PRF and i-PRF on Clinical and Biochemical Parameters in Non-Surgical Periodontal Therapy
NA trial testing Non-surgical periodontal therapy (NSPT) in Periodontitis in 56 participants. Completed in 25 December 2025.
5 August 2025
Quick facts
| Lead sponsor | Ondokuz Mayıs University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 56 |
| Start date | 20 April 2024 |
| Primary completion | 5 August 2025 |
| Estimated completion | 25 December 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Non-surgical periodontal therapy (NSPT)
- Platelet-rich fibrin (PRF)
- Injectable platelet-rich fibrin (i-PRF) — full drug profile →
Conditions studied
- Periodontitis — all drugs for Periodontitis →
Sponsor
Ondokuz Mayıs University
Who can join
18 and older, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to learn if adding platelet-rich fibrin (PRF) or injectable platelet-rich fibrin (i-PRF), obtained from the participant's own blood, to standard non-surgical periodontal treatment helps improve gum health in individuals with periodontitis. It will also assess how these applications affect inflammation and bone-related markers in the gum fluid. The main questions it aims to answer are : * Does the application of PRF or i-PRF improve clinical periodontal healing compared to standard treatment alone? * Do these applications influence the levels of inflammatory and bone metabolism-related biomarkers in gingival crevicular fluid? Researchers will compare patients receiving PRF or i-PRF in addition to standard periodontal treatment with those receiving standard treatment alone. In addition, the findings obtained from individuals with periodontal disease will be compared with data from periodontally healthy individuals. Participants will: * Receive standard periodontal treatment (scaling and root planing) * Receive PRF or i-PRF depending on their assigned group * Visit the clinic before treatment and at 2, 4, and 6 weeks after treatment for checkups
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07525531
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Non-surgical periodontal therapy (NSPT)
Trials testing the same drug.
- NCT07524504 — Predictive Role of the Full-mouth Plaque Score on the Outcomes of Non-surgical Periodontal Therapy. · not yet recruiting
Other recruiting trials for Periodontitis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
- NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
- NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
- NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting
Other Ondokuz Mayıs University trials
Trials by the same sponsor.
- NCT07500389 — Postural Habits, Body Awareness, and Functional Performance Across BMI Categories in Women · not yet recruiting
- NCT07535242 — Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS · not yet recruiting
- NCT07504848 — Stroke Mobility and Caregiver Outcomes · not yet recruiting
- NCT07525557 — Kinesiophobia, Pain and Disability in Chronic Neck Pain · recruiting
- NCT07497802 — Mindfulness-Based Psychoeducation for Women With Gynecological Cancer · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07525531 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ondokuz Mayıs University
- Last refreshed: 15 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07525531.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing