NCT07518459 is a Phase 1 clinical trial of [14C]AZD4144 Solution for Infusion in Healthy Participants, sponsored by AstraZeneca.

Who is sponsoring NCT07518459?

NCT07518459 is sponsored by AstraZeneca.

What drugs are being tested in NCT07518459?

Interventions in NCT07518459: [14C]AZD4144 Solution for Infusion, [14C]AZD4144 Oral Solution.

What condition does NCT07518459 study?

NCT07518459 studies Healthy Participants.

Is NCT07518459 still recruiting?

NCT07518459 is currently active, enrolled. Last updated 8 April 2026.

Last reviewed 2026-04-08 · How we verify

NCT07518459

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Study of Absorption, Distribution, Metabolism and Excretion (ADME) of [14C]AZD4144

Active, enrolled Phase 1 Last updated 8 April 2026

What this trial tests

Phase 1 trial testing [14C]AZD4144 Solution for Infusion in Healthy Participants in 8 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

11 February 2026

Primary endpoint
28 May 2026

28 May 2026

Quick facts

Lead sponsor	AstraZeneca
Phase	Phase 1
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	8
Start date	11 February 2026
Primary completion	28 May 2026
Estimated completion	28 May 2026
Sites	1 location across United Kingdom

Drugs / interventions tested

[14C]AZD4144 Solution for Infusion
[14C]AZD4144 Oral Solution

Conditions studied

Healthy Participants — all drugs for Healthy Participants →

Sponsor

AstraZeneca — full company profile →

Who can join

Adults 30 to 65, any sex, with Healthy Participants. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study in healthy volunteers aims to explore blood levels and side effects of the test medicine, and look at how it is broken down when injected into a vein or given as a liquid by mouth. The test medicine will be radiolabeled with a small amount of carbon-14 so it can be tracked in the body. This study will take place at one site in Nottingham, United Kingdom, and will enroll 2 groups of 8 healthy men aged 30-65 years.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Other AstraZeneca trials

Trials by the same sponsor.

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NCT07516184 — Explore the Diagnostic Value of Bronchodilation Test With Portable Oscillometry in Asthma Diagnosis · NA · not yet recruiting
NCT07279935 — Osimertinib Combined With Chemotherapy in Patients Who Had Distant Recurrence After Adjuvant Osimertinib for EGFRm Resec · Phase 4 · not yet recruiting
NCT07279948 — A Single-arm Observational Study to Characterize the Demographic, Clinical Features and Outcomes of a Brazilian Cohort o · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07518459 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by AstraZeneca
Last refreshed: 8 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07518459.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing