Last reviewed · How we verify
NCT07517991: CHX-Zn
Chlorhexidine and Zinc in Non-Surgical Periodontal Therapy
NA trial testing Chlorhexidine and zinc application in Periodontitis in 44 participants. Completed in 1 April 2026.
26 March 2026
Quick facts
| Lead sponsor | Ataturk University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 44 |
| Start date | 16 June 2025 |
| Primary completion | 26 March 2026 |
| Estimated completion | 1 April 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Chlorhexidine and zinc application
- Scaling and root planing with distilled water
Conditions studied
- Periodontitis — all drugs for Periodontitis →
- Periodontitis Stage I — all drugs for Periodontitis Stage I →
- Periodontitis Stage II — all drugs for Periodontitis Stage II →
Sponsor
Ataturk University
Who can join
Adults 18 to 65, any sex, with Periodontitis or Periodontitis Stage I. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth and is associated with both local tissue destruction and systemic inflammatory responses. Non-surgical periodontal therapy, particularly scaling and root planing (SRP), is the primary treatment approach; however, it may not completely eliminate pathogenic microorganisms in all cases. Adjunctive antimicrobial agents may improve treatment outcomes by enhancing bacterial reduction and modulating inflammation. Chlorhexidine (CHX) is widely used for its antimicrobial properties, while zinc has anti-inflammatory and immunomodulatory effects. The combined use of CHX and zinc may provide synergistic benefits in periodontal therapy. The aim of this randomized controlled clinical trial is to evaluate the clinical and biochemical effects of CHX and zinc as adjuncts to SRP in individuals with stage I and II periodontitis. A total of 44 systemically healthy participants will be randomly assigned to two groups. The test group will receive SRP with CHX and zinc, while the control group will receive SRP with distilled water. Clinical periodontal parameters (Plaque Index, Bleeding on Probing, Probing Pocket Depth, and Clinical Attachment Level) and biochemical markers (C-reactive protein, high-sensitivity CRP, Oncostatin M, and Antistreptolysin O) will be evaluated at baseline, 1 month, and 3 months. The results of this study are expected to provide evidence regarding the potential benefits of CHX and zinc in improving periodontal treatment outcomes and reducing systemic inflammation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07517991
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periodontitis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
- NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
- NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
- NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting
Other Ataturk University trials
Trials by the same sponsor.
- NCT07518537 — Bulk-Fill Composite Restorations: Clinical Evaluation · NA · not yet recruiting
- NCT07241156 — Creative Drama on Gender Role Stress, Attitudes Toward Violence Against Women, and Aggression · NA · not yet recruiting
- NCT07451418 — The Effect of Mindfulness Compassionate Living Training on Unwanted Pregnancies · NA · not yet recruiting
- NCT07464548 — Effects of Stoma Education on Patients · NA · recruiting
- NCT07375277 — Effects Of Biceps Transposition Without Tenotomy For Augmentation Of Massive Rotator Cuff Repairs · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07517991 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ataturk University
- Last refreshed: 8 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07517991.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing