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NCT07514949: SOLUTION-ICD
The Feasibility and Safety of RK-4 Injection Bypassing Blood-brain Barrier in the Treatment of Acute Large Hemispheric Infarction Using Intracalvariosseous Injection Device
NA trial testing RK-4 ICO injection in Stroke in 6 participants. Not yet recruiting.
15 November 2026
Quick facts
| Lead sponsor | yilong Wang |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 6 |
| Start date | 15 April 2026 |
| Primary completion | 15 November 2026 |
| Estimated completion | 15 November 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- RK-4 ICO injection
- Conventional treatment — full drug profile →
Conditions studied
- Stroke — all drugs for Stroke →
- Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →
- Blood-Brain Barrier — all drugs for Blood-Brain Barrier →
Sponsor
yilong Wang — full company profile →
Who can join
Adults 18 to 80, any sex, with Stroke or Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A pilot study confirmed the feasibility and safety of neuroprotectant RK-4 intracalvariosseous(ICO) injection in patients with malignant middle cerebral artery infarction (mMCAI), showing a trend in improving 90-day functional scores compared to conventional treatment. The aim of this trial is to investigate the feasibility and safety of neuroprotective agent RK-4 injection using intracalvariosseous injection device in patients with acute large hemispheric infarction (LHI) who has contraindications of reperfusion therapy or have got poor reperfusion therapy outcomes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07514949
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other yilong Wang trials
Trials by the same sponsor.
- NCT07476352 — Expansion Study of ALT001 in Patients With Multiple System Atrophy · EARLY_PHASE1 · not yet recruiting
- NCT07514923 — The Study of Safety and Preliminary Efficacy of ALT001 in Patients With MultIple System Atrophy-Cerebellar Type · EARLY_PHASE1 · not yet recruiting
- NCT07495150 — Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis · NA · not yet recruiting
- NCT06374667 — The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Larg · NA · recruiting
- NCT05892822 — Amyotrophic Lateral Sclerosis Registry · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07514949 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by yilong Wang
- Last refreshed: 7 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07514949.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing