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NCT07514104
Extracorporeal Shock Wave Therapy in Enhancing Sensitivity and Postural Stability in Multiple Sclerosis
NA trial testing Extracorporeal Shock Wave Therapy (ESWT) in Multiple Sclerosis in 54 participants. Completed in 15 October 2025.
15 February 2025
Quick facts
| Lead sponsor | Furkan Bilek |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 54 |
| Start date | 1 July 2021 |
| Primary completion | 15 February 2025 |
| Estimated completion | 15 October 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Extracorporeal Shock Wave Therapy (ESWT)
Conditions studied
- Multiple Sclerosis — all drugs for Multiple Sclerosis →
- Multiple Sclerosis (MS) - Relapsing-remitting — all drugs for Multiple Sclerosis (MS) - Relapsing-remitting →
- Sensorimotor Gait Disorder — all drugs for Sensorimotor Gait Disorder →
Sponsor
Furkan Bilek
Who can join
Adults 18 to 65, any sex, with Multiple Sclerosis or Multiple Sclerosis (MS) - Relapsing-remitting. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial aimed to investigate the efficacy of Extracorporeal Shock Wave Therapy (ESWT) on plantar somatosensory function, knee joint proprioception, and spatiotemporal gait parameters in individuals diagnosed with Multiple Sclerosis (MS). The study included participants with a spasticity level below 1+, with the intervention group receiving ESWT three times per week over a 6-week period. To evaluate sensory changes, light touch thresholds were measured at six plantar sites-the heel, medial longitudinal arch, 1st and 5th metatarsal heads, and the 1st and 5th toes-using the Semmes-Weinstein monofilament kit. Additionally, two-point discrimination was assessed at the heel, and vibration duration was measured at the metatarsal heads using a 128 Hz tuning fork. Proprioception was quantified via the active knee joint reposition test in a closed kinetic chain position, measuring the absolute angular error at a 60° target angle. Postural stability and dynamic gait were objectively analyzed using the Win-Track platform and a reliable 3-step protocol to record parameters such as gait cycle duration, step length, cadence, and maximum plantar pressure. Static balance was further evaluated by recording the percentage of body weight transferred to each foot. By targeting both mechanoreceptor sensitivity and joint position sense, this 6-week ESWT intervention seeks to enhance the overall functional mobility and stability of MS patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07514104
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Extracorporeal Shock Wave Therapy (ESWT)
Trials testing the same drug.
- NCT07233395 — Comparison of the Effectiveness of Dextrose Prolotherapy and Extracorporeal Shock Wave Therapy (ESWT) in Plantar Fasciit · NA · not yet recruiting
- NCT07282431 — Shockwave Therapy Plus Exercise for Lateral Epicondylitis · NA · active not recruiting
- NCT07412652 — Ozone Injection vs ESWT for Chronic Achilles Tendinopathy · NA · completed
- NCT07065851 — Comparison of Shockwave Therapy and Exercise on Pain, Flexibility, and Balance in Hamstring Tightness · NA · active not recruiting
- NCT05870852 — Effectiveness of ESWT and PNF in Scleroderma With Calcinosis · NA · unknown
Other recruiting trials for Multiple Sclerosis
Currently open trials in the same condition.
- NCT07507084 — The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Wal · NA · recruiting
- NCT07524231 — Evaluation of the Effects of Laughter Yoga · NA · recruiting
- NCT07489794 — URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS · recruiting
- NCT07236684 — Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity · recruiting
- NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07514104 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Furkan Bilek
- Last refreshed: 7 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07514104.
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