NCT07509411 is a Phase 2 clinical trial of TNF-α Inhibitor in Endometriosis, sponsored by Benha University.

Who is sponsoring NCT07509411?

NCT07509411 is sponsored by Benha University.

What drugs are being tested in NCT07509411?

Interventions in NCT07509411: TNF-α Inhibitor, Frozen Blastocyst Transfer (FBT).

What condition does NCT07509411 study?

NCT07509411 studies Endometriosis.

Is NCT07509411 still recruiting?

NCT07509411 is currently active, enrolled. Last updated 3 April 2026.

Last reviewed 2026-04-03 · How we verify

NCT07509411

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Anti-TNFα Therapy for Improving Pregnancy Rates in Endometriosis Patients With Failed ICSI

Active, enrolled Phase 2 Last updated 3 April 2026

What this trial tests

Phase 2 trial testing TNF-α Inhibitor in Endometriosis in 145 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

15 August 2025

Primary endpoint
15 December 2025

15 October 2026

Quick facts

Lead sponsor	Benha University
Phase	Phase 2
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	145
Start date	15 August 2025
Primary completion	15 December 2025
Estimated completion	15 October 2026
Sites	1 location across Egypt

Drugs / interventions tested

TNF-α Inhibitor
Frozen Blastocyst Transfer (FBT)

Conditions studied

Endometriosis — all drugs for Endometriosis →

Sponsor

Benha University

Who can join

Adults 19 to 40, female only, with Endometriosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This prospective study targets infertile women with endometriosis (EM) who have experienced a previously failed Intracytoplasmic Sperm Injection (ICSI) trial. Using the P-I-C-O framework, the study evaluates whether the administration of an anti-TNF-α therapy (Intervention) 4-5 days before a frozen blastocyst transfer (FBT) improves reproductive outcomes compared to standard protocols (Comparison). The primary outcome is the clinical pregnancy rate, with secondary outcomes focusing on implantation, ongoing pregnancy, and neonatal health. The goal is to determine if mitigating pro-inflammatory cytokines like TNF-α can enhance endometrial receptivity in this specific high-risk population.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Endometriosis

Currently open trials in the same condition.

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Other Benha University trials

Trials by the same sponsor.

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NCT07300787 — miRNA in Pediatric Gastritis · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07509411 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Benha University
Last refreshed: 3 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07509411.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing