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NCT07502612: ECAP-MED Pilot
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
trial testing Spinal Cord Stimulation with Evoke Closed-Loop System in Failed Back Surgery Syndrome (FBSS) in 20 participants. Currently enrolling.
28 July 2026
Quick facts
| Lead sponsor | Brai²n |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 8 June 2022 |
| Primary completion | 28 July 2026 |
| Estimated completion | 28 August 2026 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Spinal Cord Stimulation with Evoke Closed-Loop System
Conditions studied
- Failed Back Surgery Syndrome (FBSS) — all drugs for Failed Back Surgery Syndrome (FBSS) →
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine — all drugs for Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine →
- Neurophysiological Sensitivity to Spinal Cord Stimulation — all drugs for Neurophysiological Sensitivity to Spinal Cord Stimulation →
Sponsor
Brai²n
Who can join
18 and older, any sex, with Failed Back Surgery Syndrome (FBSS) or Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS). Patients with Persistent Spinal Pain Syndrome Type 2 (FBSS/FNSS) will undergo a standard 21-day SCS trial with the Evoke closed-loop system, followed by permanent implantation if successful. Neurophysiological responses (activation plots, conduction velocity, chronaxie, rheobase) and patient-reported outcomes (VAS, activity, sleep, medication intake) will be collected during the trial and up to 6 months after implantation. The goal is to evaluate the relationship between medication tapering and spinal cord sensitivity
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07502612
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Spinal Cord Stimulation with Evoke Closed-Loop System
Trials testing the same drug.
- NCT07413731 — Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation · recruiting
Other Brai²n trials
Trials by the same sponsor.
- NCT07413731 — Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07502612 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brai²n
- Last refreshed: 31 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07502612.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing