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NCT07480538: GCF-OTM
GCF Volume Changes in Aligners and Fixed Appliances
NA trial testing Clear Aligner Therapy in Orthodontic Tooth Movement in 32 participants. Completed in 3 March 2026.
11 February 2026
Quick facts
| Lead sponsor | Suleyman Demirel University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 3 June 2025 |
| Primary completion | 11 February 2026 |
| Estimated completion | 3 March 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Clear Aligner Therapy
- Fixed Appliance
Conditions studied
- Orthodontic Tooth Movement — all drugs for Orthodontic Tooth Movement →
Sponsor
Suleyman Demirel University
Who can join
14 and older, any sex, with Orthodontic Tooth Movement. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Orthodontic tooth movement induces biological responses in periodontal tissues that can be reflected by changes in gingival crevicular fluid (GCF). This study aims to evaluate temporal changes in GCF volume during orthodontic treatment with clear aligners and conventional fixed appliances. GCF samples will be collected from the buccal site of tooth 12 and the palatal site of tooth 16 at baseline, 1 hour, 1 day, 1 week, and 1 month after appliance placement. The findings of this study will help to better understand periodontal tissue responses associated with different orthodontic treatment modalities.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07480538
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Orthodontic Tooth Movement
Currently open trials in the same condition.
- NCT07399483 — Evaluation of the Biomechanical Response of Orthodontic Tooth Movement to Clear Aligner vs Fixed Orthodontic Appliance · NA · active not recruiting
Other Suleyman Demirel University trials
Trials by the same sponsor.
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- NCT07245355 — Contribution of Recreational Exercises to Balance and Muscle Strength in Osteoporosis Risk · NA · not yet recruiting
- NCT07333391 — Individualized Grief Support With Swanson Model · NA · not yet recruiting
- NCT07382830 — Effectiveness of a Visual Feedback Exercise Program Following Lumbar Surgery · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07480538 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Suleyman Demirel University
- Last refreshed: 18 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07480538.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing