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NCT07474974: BRIGHT
ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder
NA trial testing Repetitive transcranial magnetic stimulation (rTMS) in Depression - Major Depressive Disorder in 44 participants. Not yet recruiting.
30 April 2027
Quick facts
| Lead sponsor | Polytechnic Institute of Porto |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 44 |
| Start date | 15 March 2026 |
| Primary completion | 30 April 2027 |
| Estimated completion | 31 July 2027 |
Drugs / interventions tested
- Repetitive transcranial magnetic stimulation (rTMS)
Conditions studied
- Depression - Major Depressive Disorder — all drugs for Depression - Major Depressive Disorder →
- Treatment Resistant Depression — all drugs for Treatment Resistant Depression →
Sponsor
Polytechnic Institute of Porto
Who can join
Adults 18 to 65, any sex, with Depression - Major Depressive Disorder or Treatment Resistant Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research explores the potential of retinal ganglion cells (RGCs), particularly intrinsically photosensitive RGCs (ipRGCs), as biomarkers for predicting response to transcranial magnetic stimulation (TMS) in treatment-resistant depression (TRD). We also aim to assess the impact of TMS treatment on RGCs and ipRGCs in TRD patients, investigating associations with clinical improvements and cognitive status. A clinical trial involving 44 patients with treatment-resistant depression (TRD) will be conducted. All participants will receive rTMS targeting the dorsolateral prefrontal cortex (DLPFC). Data will be collected pre- and post-intervention, as well as at a 2-month follow-up, using multiple outcome measures, including the post-illumination pupil response (PIPR). The project seeks to confirm the effectiveness of TMS and the potential of RGCs/ipRGCs as predictors of treatment response, thereby facilitating the development of personalized treatment strategies for TRD patients undergoing rTMS therapy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07474974
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07474974 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Polytechnic Institute of Porto
- Last refreshed: 16 March 2026
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