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NCT07472998: BPPV-HRV
Heart Rate Variability in Benign Paroxysmal Positional Vertigo
trial testing Short-term HRV measurement in BPPV in 104 participants. Currently enrolling.
1 August 2026
Quick facts
| Lead sponsor | Istanbul Aydın University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 104 |
| Start date | 1 April 2026 |
| Primary completion | 1 August 2026 |
| Estimated completion | 1 September 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Short-term HRV measurement
Conditions studied
- BPPV — all drugs for BPPV →
- Stress and Anxiety — all drugs for Stress and Anxiety →
Sponsor
Istanbul Aydın University
Who can join
Adults 18 to 65, any sex, with BPPV or Stress and Anxiety. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder. Although the pathophysiology of BPPV is mainly attributed to the displacement of otoconia within the semicircular canals, recent studies suggest that psychological stress and anxiety may be associated with the onset or recurrence of the disease. However, the biological mechanisms underlying this relationship remain poorly understood, and objective evaluation of autonomic nervous system function in patients with BPPV is limited. Heart rate variability (HRV) is a non-invasive method widely used to assess autonomic nervous system activity. Short-term HRV measurements provide information about autonomic balance and vagal tone. In particular, parameters such as the root mean square of successive differences (RMSSD) and the coefficient of variation of RR intervals (COV RR/R) are considered indicators of parasympathetic activity. The aim of this prospective case-control study is to evaluate vagal tone in patients with BPPV using short-term HRV analysis and to compare the findings with age-, sex-, and body mass index-matched healthy controls. Participants will undergo standardized HRV measurements at rest and during controlled breathing. Perceived stress levels will also be assessed using the Perceived Stress Scale (PSS-10). The primary outcomes of the study are RMSSD and the coefficient of variation of RR intervals (COV RR/R), obtained from short-term HRV recordings. These parameters will be compared between BPPV patients and healthy controls, and their associations with perceived stress levels will also be explored. The findings of this study may provide insights into the role of autonomic regulation and stress-related mechanisms in the pathophysiology of BPPV.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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- PubMed search for NCT07472998
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07472998 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istanbul Aydın University
- Last refreshed: 16 April 2026
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