Motor and Cognitive Exercise in Parkinson's Disease. (Ex-Park)

NCT07465107 NA RECRUITING

The aim of this study is to examine the effects of a specialized multi-modal intervention in patients with moderate to advanced Parkinson's disease (PD). The hypothesis is that a specialized motor- and cognitive exercise program in addition to usual care can improve gait and balance better than usual care alone. 48 patients with PD and a symptom duration of 4 or more years will be randomized 1:1 to either a control arm or to an intervention arm. The control arm will have usual management of their PD. The intervention arm will receive exercises aimed at both motor and cognitive impairments of PD over the course of 12 weeks. The study has been designed in partnership with the Copenhagen Trial Unit (CTU), Copenhagen Univeristy Hospital, to ensure both internal and external validity. To increase reproducibility, detailed protocols for all training modalities will be shared along with the study results. This study is a feasibility study with the intention of a following international multi-center study to corroborate the results. Both feasibility outcomes for the intervention itself and clinical outcomes for the participants will be published.

Details

Lead sponsor	Annemette Lokkegaard
Phase	NA
Status	RECRUITING
Enrolment	48
Start date	Wed Mar 26 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sun Feb 14 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Parkinson Disease (PD)

Interventions

• Motor-cognitive exercise
• Usual Care

Countries

Denmark