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NCT07451990
Comparison of Vicryl Versus Prolene for Midline Rectus Sheath Closure After Elective Laparotomy
NA trial testing Vicryl (Polyglactin 910) Suture in Laparotomy Closure After Abdominal Surgery in 152 participants. Completed in 30 November 2025.
30 October 2025
Quick facts
| Lead sponsor | Hayatabad Medical Complex |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 152 |
| Start date | 1 April 2024 |
| Primary completion | 30 October 2025 |
| Estimated completion | 30 November 2025 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Vicryl (Polyglactin 910) Suture
- Prolene (Polypropylene) Suture
Conditions studied
- Laparotomy Closure After Abdominal Surgery — all drugs for Laparotomy Closure After Abdominal Surgery →
- Suture Materials — all drugs for Suture Materials →
- Complications Wounds — all drugs for Complications Wounds →
Sponsor
Hayatabad Medical Complex — full company profile →
Who can join
Adults 18 to 70, any sex, with Laparotomy Closure After Abdominal Surgery or Suture Materials. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial compared two commonly used suture materials, Prolene and Vicryl, for closing the midline rectus sheath after elective laparotomy. Proper closure of the abdominal wall is important to reduce complications such as wound dehiscence and surgical site infection. Adult patients undergoing elective midline laparotomy were randomly assigned to rectus sheath closure using either Prolene or Vicryl sutures. All patients received the same standardized surgical technique and postoperative care. Participants were followed for 30 days after surgery to assess wound healing, wound dehiscence, surgical site infection, and length of hospital stay. The study aimed to determine which suture material is associated with fewer postoperative wound complications.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07451990
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Laparotomy Closure After Abdominal Surgery
Currently open trials in the same condition.
- NCT05804136 — Duramesh™ vs Polydioxanone Suture for Laparotomy Closure · NA · recruiting
Other Hayatabad Medical Complex trials
Trials by the same sponsor.
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- NCT07422558 — Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain · NA · not yet recruiting
- NCT07233382 — Assessing the Efficacy of Probiotics in Prevention of NEC in Preterm Babies · NA · not yet recruiting
- NCT05756504 — "NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis? · EARLY_PHASE1 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07451990 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hayatabad Medical Complex
- Last refreshed: 5 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07451990.
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