NCT07448896 is a clinical trial of bariatric surgery laparoscopic sleeve gastrectomy in Obesity, sponsored by General Committee of Teaching Hospitals and Institutes, Egypt.

Who is sponsoring NCT07448896?

NCT07448896 is sponsored by General Committee of Teaching Hospitals and Institutes, Egypt.

What drugs are being tested in NCT07448896?

Interventions in NCT07448896: bariatric surgery laparoscopic sleeve gastrectomy, lean control patients undergoing endoscopic biopsy for benign or malignant gastric conditions..

Is NCT07448896 still recruiting?

NCT07448896 is currently recruiting now. Last updated 24 April 2026.

Last reviewed 2026-04-24 · How we verify

NCT07448896

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Understanding Alterations in Mast Cell and Macrophage Infiltration, as Well as Micro Vessel Density, May Throw Light on the Early Events Leading to Gastric Carcinogenesis in Obesity

Recruiting now Last updated 24 April 2026

What this trial tests

trial testing bariatric surgery laparoscopic sleeve gastrectomy in Obesity in 100 participants. Currently enrolling.

Timeline

15 April 2026

Primary endpoint
1 May 2026

1 May 2026

Quick facts

Lead sponsor	General Committee of Teaching Hospitals and Institutes, Egypt
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	100
Start date	15 April 2026
Primary completion	1 May 2026
Estimated completion	1 May 2026
Sites	1 location across Egypt

Drugs / interventions tested

bariatric surgery laparoscopic sleeve gastrectomy
lean control patients undergoing endoscopic biopsy for benign or malignant gastric conditions.

Conditions studied

Obesity — all drugs for Obesity →

Sponsor

General Committee of Teaching Hospitals and Institutes, Egypt

Who can join

Eligibility, any sex, with Obesity. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Immunohistochemistry
Time frame: Baseline
Compare the 2 groups: Adipose tissue macrophages (ATMs) was assessed by immunohistochemistry using a three-step biotin-avidin-peroxidase detection method. five-micrometer-thick serial sections were cut from formalin-fixed, paraffin-embedded gastric tissue of obese (GTO) and control normal tissue (NT) samples. Antigen retrieval was performed using a microwave oven (500 W for 10 minutes), followed
Immunohistochemistry
Time frame: Baseline
Compare the 2 groups: Mast cells positive for tryptase (MCPT) was assessed by immunohistochemistry using a three-step biotin-avidin-peroxidase detection method. five-micrometer-thick serial sections were cut from formalin-fixed, paraffin-embedded gastric tissue of obese (GTO) and control normal tissue (NT) samples. Antigen retrieval was performed using a microwave oven (500 W for 10 minutes), fol
Immunohistochemistry
Time frame: Baseline
Compare the 2 groups: Microvascular density (MVD) was assessed by immunohistochemistry using a three-step biotin-avidin-peroxidase detection method. five-micrometer-thick serial sections were cut from formalin-fixed, paraffin-embedded gastric tissue of obese (GTO) and control normal tissue (NT) samples. Antigen retrieval was performed using a microwave oven (500 W for 10 minutes), followed by end
Morphometric Analysis
Time frame: Baseline
Compare the 2 groups: Quantitative assessment was performed using a light microscope. For GTO tissue section, five highly immunostained areas ("hot spots") were identified at low magnification. ATMs, MCPT, and MVD were then quantified at ×40 magnification. The mean value across five hot spots per marker was used for each sample. To evaluate mast cell degranulation, the presence of tryptase-posit
Morphometric analysis
Time frame: Baseline
Compare the 2 groups: Quantitative assessment was performed using a light microscope. For NT tissue section, five highly immunostained areas ("hot spots") were identified at low magnification. ATMs, MCPT, and MVD were then quantified at ×40 magnification. The mean value across five hot spots per marker was used for each sample. To evaluate mast cell degranulation, the presence of tryptase-positi

Sponsor's own description

Obesity is a global health problem that has reached epidemic proportions, affecting more than one billion people worldwide and significantly increasing the risk of multiple comorbidities, including type 2 diabetes, cardiovascular diseases, and cancer (World Health Organization, 2024). Increasing evidence suggests that chronic low-grade inflammation associated with obesity plays a critical role in the development of obesity-related malignancies, including gastric cancer. Adipose tissue dysfunction in obesity leads to the recruitment and activation of various immune cells, such as macrophages and mast cells, which contribute to a pro-inflammatory microenvironment through the release of cytokines, growth factors, and angiogenic mediators.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Obesity

Currently open trials in the same condition.

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NCT07481630 — A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoart · Phase 3 · recruiting
NCT07527195 — Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscl · Phase 1 · recruiting

Other General Committee of Teaching Hospitals and Institutes, Egypt trials

Trials by the same sponsor.

NCT06981923 — Awake Bedside Assessment of The Airway and Evaluation of Tracheal Intubation With CMAC D-Blade or Video Stylet in Bariat · NA · completed
NCT06787924 — Impact of Collagen Supplements on Dermal Collagen in Plastic and Bariatric Surgery Patients · NA · completed
NCT06510452 — Antibiotic Prophylaxis in Metabolic Bariatric Surgery · NA · not yet recruiting
NCT06049758 — D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy · NA · not yet recruiting
NCT05982951 — A Comparative Study Between Ultrasound Guided Shoulder Block and Pericapsular Nerve Group Bock for Shoulder Arthroscopic · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07448896 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by General Committee of Teaching Hospitals and Institutes, Egypt
Last refreshed: 24 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07448896.

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