Last reviewed · How we verify
NCT07431918: VRELAX
Effects of Nature-Based Virtual Reality and Binaural Beats on Heart Rate Variability and Relaxation
NA trial testing Nature-Based Virtual Reality With Binaural Beats in Stress in 18 participants. Not yet recruiting.
20 December 2026
Quick facts
| Lead sponsor | Heart and Brain Research Group, Germany |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 18 |
| Start date | 25 February 2026 |
| Primary completion | 20 December 2026 |
| Estimated completion | 20 December 2026 |
Drugs / interventions tested
- Nature-Based Virtual Reality With Binaural Beats
Conditions studied
- Stress — all drugs for Stress →
- Relaxation — all drugs for Relaxation →
- Virtual Reality — all drugs for Virtual Reality →
- Binaural Beats — all drugs for Binaural Beats →
Sponsor
Heart and Brain Research Group, Germany
Who can join
18 and older, any sex, with Stress or Relaxation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The VRELAX study is a non-clinical sub-study within the "Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients"- research program (DESTRESS; NCT05036538), which investigates non-pharmacological relaxation interventions using virtual reality and binaural auditory stimulation. In a randomized counterbalanced within-subject design, non-clinical adult participants complete two sessions separated by a 1 day intervention-free interval. A 30-minute immersive nature-based virtual reality exposure combined with gradually decreasing binaural beats (10-1 Hertz (Hz)), and a control condition without relaxation. Heart rate variability (HRV) is recorded continuously, and subjective stress is assessed before and after each condition. The primary outcome is parasympathetic activation operationalized as high-frequency (HF) power of heart rate variability. Secondary outcomes include additional HRV parameters and self-reported stress ratings. The study aims to characterize short-term relaxation effects and evaluate the feasibility of independent use in everyday settings, supporting interpretation of clinical findings of the DESTRESS trial.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07431918
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Heart and Brain Research Group, Germany trials
Trials by the same sponsor.
- NCT07387107 — Decreasing Stress Via Virtual Reality and Binaural Beats in Non-Clinical Adults · NA · recruiting
- NCT04535076 — Cognitive Outcome After Surgical and Transcatheter Aortic Valve Replacement · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07431918 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Heart and Brain Research Group, Germany
- Last refreshed: 25 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07431918.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing